UniProt functional annotation for Q8R3P2



	UniProt functional annotation for Q8R3P2

UniProt code: Q8R3P2.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). {ECO:0000250}.

Catalytic activity: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q61010};

Pathway: Protein modification; protein ubiquitination.

Subunit: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. {ECO:0000269|PubMed:11226752}.

Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86UW9}. Nucleus {ECO:0000250|UniProtKB:Q86UW9}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250|UniProtKB:Q86UW9}.

Tissue specificity: Expressed in testis and the CNS. {ECO:0000269|PubMed:11226752}.

Developmental stage: In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly earlier that Dtx1 and Dtx3. {ECO:0000269|PubMed:11226752}.

Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. {ECO:0000250}.

Disease: Note=Recurrent site of retroviral integration in murine B-cell lymphomas.

Miscellaneous: [Isoform 3]: Splicing donor site not canonical. {ECO:0000305}.

Similarity: Belongs to the Deltex family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). {ECO:0000250}.


Catalytic activity:		Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250\|UniProtKB:Q61010};
Pathway:		Protein modification; protein ubiquitination.
Subunit:		Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. {ECO:0000269\|PubMed:11226752}.
Subcellular location:		Cytoplasm {ECO:0000250\|UniProtKB:Q86UW9}. Nucleus {ECO:0000250\|UniProtKB:Q86UW9}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250\|UniProtKB:Q86UW9}.
Tissue specificity:		Expressed in testis and the CNS. {ECO:0000269\|PubMed:11226752}.
Developmental stage:		In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly earlier that Dtx1 and Dtx3. {ECO:0000269\|PubMed:11226752}.
Domain:		The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. {ECO:0000250}.
Disease:		Note=Recurrent site of retroviral integration in murine B-cell lymphomas.
Miscellaneous:		[Isoform 3]: Splicing donor site not canonical. {ECO:0000305}.
Similarity:		Belongs to the Deltex family. {ECO:0000305}.