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UniProt functional annotation for Q9P2W7 | ||
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| UniProt code: Q9P2W7. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. {ECO:0000250|UniProtKB:O35789}. |
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| Catalytic activity: | |
Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP; Xref=Rhea:RHEA:24168, Rhea:RHEA-COMP:12571, Rhea:RHEA-COMP:12573, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132090, ChEBI:CHEBI:132093; EC=2.4.1.135; Evidence={ECO:0000250|UniProtKB:O35789}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| Pathway: | |
Protein modification; protein glycosylation. |
| Subunit: | |
Homodimer. Interacts with SAR1A. {ECO:0000250|UniProtKB:O35789}. |
| Subcellular location: | |
[Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}. |
| Subcellular location: | |
[Isoform 2]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789}. |
| Tissue specificity: | |
Mainly expressed in the brain. |
| Ptm: | |
The soluble form derives from the membrane form by proteolytic processing. {ECO:0000250|UniProtKB:O35789}. |
| Similarity: | |
Belongs to the glycosyltransferase 43 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.