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UniProt functional annotation for Q8K4I3 | ||
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| UniProt code: Q8K4I3. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Acts as a RAC1 guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
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| Subunit: | |
Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Interacts with BIN2. Identified in a complex with BIN2 and GIT2 (By similarity). Interacts with PARVB. {ECO:0000250, ECO:0000269|PubMed:18325335}. |
| Subcellular location: | |
Cell projection, lamellipodium {ECO:0000269|PubMed:18325335}. |
| Tissue specificity: | |
Detected in adult heart, spleen, lung, skeletal muscle, kidney and testis. Detected throughout embryogenesis. {ECO:0000269|PubMed:12063400}. |
Annotations taken from UniProtKB at the EBI.