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UniProt functional annotation for Q14565 | ||
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| UniProt code: Q14565. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000269|PubMed:21307306}. |
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| Subunit: | |
Double stacked ring-shaped homooctamer (PubMed:15125839). Interacts with BRCA2 (PubMed:20729832). Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination (PubMed:21307306, PubMed:21903585). {ECO:0000250|UniProtKB:Q61880, ECO:0000269|PubMed:15125839, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:21903585}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:Q61880}. Chromosome {ECO:0000250|UniProtKB:Q61880}. |
| Similarity: | |
Belongs to the RecA family. DMC1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.