UniProt functional annotation for Q6ZPE2



	UniProt functional annotation for Q6ZPE2

UniProt code: Q6ZPE2.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. {ECO:0000250|UniProtKB:O95248}.

Subunit: Heterodimer with lipid phosphatase MTMR2. Interacts with KMT2A/MLL1 (via SET domain). Interacts with SUV39H1. {ECO:0000250|UniProtKB:O95248}.

Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95248}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95248}.

Domain: The C-terminal domain mediates interaction with MTMR2. {ECO:0000250|UniProtKB:O95248}.

Similarity: Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAH29156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC98295.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. {ECO:0000250\|UniProtKB:O95248}.


Subunit:		Heterodimer with lipid phosphatase MTMR2. Interacts with KMT2A/MLL1 (via SET domain). Interacts with SUV39H1. {ECO:0000250\|UniProtKB:O95248}.
Subcellular location:		Cytoplasm {ECO:0000250\|UniProtKB:O95248}. Cytoplasm, perinuclear region {ECO:0000250\|UniProtKB:O95248}.
Domain:		The C-terminal domain mediates interaction with MTMR2. {ECO:0000250\|UniProtKB:O95248}.
Similarity:		Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAH29156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC98295.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};