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PDBsum entry 1v3p
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References listed in PDB file
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Key reference
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Title
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Crystal structures of a DNA octaplex with i-Motif of g-Quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats.
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Authors
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J.Kondo,
W.Adachi,
S.Umeda,
T.Sunami,
A.Takénaka.
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Ref.
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Nucleic Acids Res, 2004,
32,
2541-2549.
[DOI no: ]
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PubMed id
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Abstract
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Recent genomic analyses revealed many kinds of tandem repeats of specific
sequences. Some of them are related to genetic diseases, but their biological
functions and structures are still unknown. Two X-ray structures of a short DNA
fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled
to form an octaplex at a low K+ concentration, in which the eight G5 residues
form a stacked double G-quartet in the central part. At a higher K+
concentration, however, the octaplex is split into just two halves. These
structural features suggest a folding process of eight tandem repeats of
d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the
repeats could facilitate slippage of a certain sequence during DNA replication,
to induce increase or decrease of the repeats.
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Headers
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