UniProt functional annotation for P57725



	UniProt functional annotation for P57725

UniProt code: P57725.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. {ECO:0000269|PubMed:15381729, ECO:0000269|PubMed:19923443, ECO:0000269|PubMed:20478393, ECO:0000269|PubMed:21296879}.

Subunit: Interacts with FASLG (By similarity). Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1. {ECO:0000250, ECO:0000269|PubMed:15381729, ECO:0000269|PubMed:20478393, ECO:0000269|PubMed:21296879}.

Subcellular location: Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.

Tissue specificity: Detected in spleen and lymph node (at protein level). {ECO:0000269|PubMed:15381729}.

Induction: Up-regulated in peripheral blood B-cells by IL4 and bacterial lipopolysaccharide (LPS). {ECO:0000269|PubMed:15381729}.

Disruption phenotype: No visible phenotype. Mice have normal bone marrow B-cell development and normal splenic T- and B-cell populations, but show an enhanced immune response upon immunization. Mice have constitutively activated Lyn, due to constitutive Lyn tyrosine phosphorylation. {ECO:0000269|PubMed:19923443}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. {ECO:0000269\|PubMed:15381729, ECO:0000269\|PubMed:19923443, ECO:0000269\|PubMed:20478393, ECO:0000269\|PubMed:21296879}.


Subunit:		Interacts with FASLG (By similarity). Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1. {ECO:0000250, ECO:0000269\|PubMed:15381729, ECO:0000269\|PubMed:20478393, ECO:0000269\|PubMed:21296879}.
Subcellular location:		Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
Tissue specificity:		Detected in spleen and lymph node (at protein level). {ECO:0000269\|PubMed:15381729}.
Induction:		Up-regulated in peripheral blood B-cells by IL4 and bacterial lipopolysaccharide (LPS). {ECO:0000269\|PubMed:15381729}.
Disruption phenotype:		No visible phenotype. Mice have normal bone marrow B-cell development and normal splenic T- and B-cell populations, but show an enhanced immune response upon immunization. Mice have constitutively activated Lyn, due to constitutive Lyn tyrosine phosphorylation. {ECO:0000269\|PubMed:19923443}.