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UniProt functional annotation for Q8R316 | ||
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| UniProt code: Q8R316. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). {ECO:0000250|UniProtKB:O60381, ECO:0000269|PubMed:9178770}. |
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| Subunit: | |
Binds TCF4 (By similarity). Binds RB1 (PubMed:9178770). Binds the second PAH repeat of SIN3A (PubMed:15235594). {ECO:0000250|UniProtKB:O60381, ECO:0000269|PubMed:15235594, ECO:0000269|PubMed:9178770}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15235594}. |
| Ptm: | |
Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. {ECO:0000250|UniProtKB:O60381}. |
| Sequence caution: | |
Sequence=BAC38611.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.