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UniProt functional annotation for P25604 | ||
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| UniProt code: P25604. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1. {ECO:0000269|PubMed:10207082, ECO:0000269|PubMed:11208108, ECO:0000269|PubMed:11511343}. |
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| Subunit: | |
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Interacts with HSE1 and VPS27. Interacts with MVB12 and SRN2. {ECO:0000269|PubMed:11511343, ECO:0000269|PubMed:12900393, ECO:0000269|PubMed:15086794, ECO:0000269|PubMed:16615893, ECO:0000269|PubMed:16615894, ECO:0000269|PubMed:17442384}. |
| Subcellular location: | |
Cytoplasm. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. |
| Domain: | |
The UEV domain is required for the interaction of the complex with ubiquitin. |
| Miscellaneous: | |
Present with 1360 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}. |
| Sequence caution: | |
Sequence=CAC42964.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.