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UniProt functional annotation for Q7T2Q1 | ||
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| UniProt code: Q7T2Q1. |
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| Organism: | |
Echis multisquamatus (Central Asian sand viper). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae; Echis. |
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| Function: | |
EMS16 is a potent and selective inhibitor of alpha-2/beta-1 (ITGA2/ITGB1) integrin and acts as a potent antagonist of platelet aggregation and cell migration. Binds specifically to the I domain of the alpha-2 subunit, in a metal ion-independent fashion. |
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| Subunit: | |
Heterodimer of subunits A and B; disulfide-linked. {ECO:0000269|PubMed:14580195, ECO:0000269|PubMed:15276841}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.