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UniProt functional annotation for P26992 | ||
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| UniProt code: P26992. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). {ECO:0000269|PubMed:26858303}. |
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| Subunit: | |
Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF- 1 (PubMed:26858303). Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation (PubMed:26858303). {ECO:0000269|PubMed:26858303}. |
| Subcellular location: | |
Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue specificity: | |
Nervous system and skeletal muscle. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 3 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.