UniProt functional annotation for Q9JKE2



	UniProt functional annotation for Q9JKE2

UniProt code: Q9JKE2.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q9NP99, ECO:0000269|PubMed:23241959, ECO:0000269|PubMed:27328755}.

Subunit: Monomer (PubMed:15561137). Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4 (By similarity). {ECO:0000250|UniProtKB:Q9NP99, ECO:0000269|PubMed:15561137}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9NP99}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NP99}. Note=Recruited to lipid rafts when activated. {ECO:0000250|UniProtKB:Q9NP99}.

Disruption phenotype: Deletion mutants do not show any influence of the antiviral T-cell response. However, TREM1 deficiency impairs secretion of CCL2 and TNF-alpha by neutrophils in response to viruses (PubMed:27328755). TREM-1/3-deficient animals have decreased neutrophils in the airway and these neutrophils have a defect in transepithelial migration (PubMed:23241959). {ECO:0000269|PubMed:23241959, ECO:0000269|PubMed:27328755}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity). {ECO:0000250\|UniProtKB:Q9NP99, ECO:0000269\|PubMed:23241959, ECO:0000269\|PubMed:27328755}.


Subunit:		Monomer (PubMed:15561137). Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4 (By similarity). {ECO:0000250\|UniProtKB:Q9NP99, ECO:0000269\|PubMed:15561137}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q9NP99}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q9NP99}. Note=Recruited to lipid rafts when activated. {ECO:0000250\|UniProtKB:Q9NP99}.
Disruption phenotype:		Deletion mutants do not show any influence of the antiviral T-cell response. However, TREM1 deficiency impairs secretion of CCL2 and TNF-alpha by neutrophils in response to viruses (PubMed:27328755). TREM-1/3-deficient animals have decreased neutrophils in the airway and these neutrophils have a defect in transepithelial migration (PubMed:23241959). {ECO:0000269\|PubMed:23241959, ECO:0000269\|PubMed:27328755}.