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UniProt functional annotation for Q60980 | ||
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| UniProt code: Q60980. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. {ECO:0000269|PubMed:15684403, ECO:0000269|PubMed:8657145}. |
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| Subunit: | |
Monomer. {ECO:0000269|PubMed:12736264}. |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Tissue specificity: | |
In 8.5 day embryos, expressed in midbrain, anterior hindbrain and ventral forebrain. In 9 day embryos, expressed throughout ventral anterior half of embryo including midbrain-hindbrain junction, ventral midbrain, diencephalon and forebrain. At 10.5 days, distribution is more widespread with expression also found in developing limb buds. Widely expressed in the adult. {ECO:0000269|PubMed:8657145}. |
| Domain: | |
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF3, the motif is inactive. {ECO:0000250|UniProtKB:P57682}. |
| Ptm: | |
Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-197 is the major site. {ECO:0000269|PubMed:15684403}. |
| Similarity: | |
Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.