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PDBsum entry 1ttf
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Glycoprotein PDB id
1ttf

 

 

 

 

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Contents
Protein chain
94 a.a. *
* Residue conservation analysis
PDB id:
1ttf
Name: Glycoprotein
Title: The three-dimensional structure of the tenth type iii module of fibronectin: an insight into rgd-mediated interactions
Structure: Fibronectin. Chain: a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606
NMR struc: 36 models
Authors: A.L.Main,T.S.Harvey,M.Baron,I.D.Campbell
Key ref:
A.L.Main et al. (1992). The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell, 71, 671-678. PubMed id: 1423622 DOI: 10.1016/0092-8674(92)90600-H
Date:
14-Jul-93     Release date:   31-Jan-94    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P02751  (FINC_HUMAN) -  Fibronectin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		2477 a.a.
94 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
DOI no: 10.1016/0092-8674(92)90600-H Cell 71:671-678 (1992)
PubMed id: 1423622  
 
 
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions.
A.L.Main, T.S.Harvey, M.Baron, J.Boyd, I.D.Campbell.
 
  ABSTRACT  
 
The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.
 
  Selected figure(s)  
 
Figure 1.
Figure 1. The Structure of the Tenth Tpe ftl Module of Fibronectin 		Figure 5.
Figure 5. Folds of Similar Topology o the Type ll Module
 
  The above figures are reprinted by permission from Cell Press: Cell (1992, 71, 671-678) copyright 1992.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
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Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology The Atherosclerosis Risk in Communities (ARIC) Study.
  Atherosclerosis, 216, 151-156.  
21185596 D.C.Roy, S.J.Wilke-Mounts, and D.C.Hocking (2011).
Chimeric fibronectin matrix mimetic as a functional growth- and migration-promoting adhesive substrate.
  Biomaterials, 32, 2077-2087.  
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Adnectins: engineered target-binding protein therapeutics.
  Protein Eng Des Sel, 24, 3-9.  
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  Small, 7, 242-251.  
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  Biochem J, 435, 651-660.  
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  EMBO J, 29, 196-208.  
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  Biointerphases, 5, 105-113.  
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  FEBS J, 277, 2006-2014.  
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  BMC Neurosci, 11, 137.  
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  Nanomed, 1, 449-463.  
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  J Biol Chem, 275, 6680-6688.  
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  Eur J Biochem, 263, 840-848.  
  10396143 G.M.Benian, A.Ayme-Southgate, and T.L.Tinley (1999).
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  Rev Physiol Biochem Pharmacol, 138, 235-268.  
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  Biomol Eng, 16, 93-99.  
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  Biomaterials, 20, 2265-2279.  
10364233 Y.F.Liao, K.G.Wieder, J.M.Classen, and L.Van De Water (1999).
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  J Biol Chem, 274, 17876-17884.  
9782056 C.M.Goll, A.Pastore, and M.Nilges (1998).
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  Structure, 6, 1291-1302.
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  J Biol Chem, 273, 31145-31152.  
9665177 I.D.Campbell, and A.K.Downing (1998).
NMR of modular proteins.
  Nat Struct Biol, 5, 496-499.  
9700498 I.D.Campbell (1998).
The modular architecture of leukocyte cell-surface receptors.
  Immunol Rev, 163, 11-18.  
9733775 J.L.Banères, F.Roquet, M.Green, H.LeCalvez, and J.Parello (1998).
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  J Biol Chem, 273, 24744-24753.  
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  J Cell Biol, 140, 197-210.  
9437430 M.Akke, J.Liu, J.Cavanagh, H.P.Erickson, and A.G.Palmer (1998).
Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.
  Nat Struct Biol, 5, 55-59.  
9727007 M.B.Wright, C.Hugo, R.Seifert, C.M.Disteche, and D.F.Bowen-Pope (1998).
Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis.
  J Biol Chem, 273, 23929-23937.  
9695813 M.J.Humphries, and P.Newham (1998).
The structure of cell-adhesion molecules.
  Trends Cell Biol, 8, 78-83.  
9647658 P.O'Grady, T.C.Thai, and H.Saito (1998).
The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR.
  J Cell Biol, 141, 1675-1684.  
9609701 S.J.Hamill, A.E.Meekhof, and J.Clarke (1998).
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  Biochemistry, 37, 8071-8079.  
  9620957 V.V.Zverlov, G.V.Velikodvorskaya, W.H.Schwarz, K.Bronnenmeier, J.Kellermann, and W.L.Staudenbauer (1998).
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  J Bacteriol, 180, 3091-3099.  
  9792099 X.Yuan, J.M.Werner, V.Knott, P.A.Handford, I.D.Campbell, and K.Downing (1998).
Effects of proline cis-trans isomerization on TB domain secondary structure.
  Protein Sci, 7, 2127-2135.  
9083105 A.R.Pickford, J.R.Potts, J.R.Bright, I.Phan, and I.D.Campbell (1997).
Solution structure of a type 2 module from fibronectin: implications for the structure and function of the gelatin-binding domain.
  Structure, 5, 359-370.  
9353344 B.Hassel, F.G.Rathjen, and H.Volkmer (1997).
Organization of the neurofascin gene and analysis of developmentally regulated alternative splicing.
  J Biol Chem, 272, 28742-28749.  
9242926 C.Chothia, and E.Y.Jones (1997).
The molecular structure of cell adhesion molecules.
  Annu Rev Biochem, 66, 823-862.  
9186052 D.E.Bovenkamp, and P.Greer (1997).
Novel Eph-family receptor tyrosine kinase is widely expressed in the developing zebrafish nervous system.
  Dev Dyn, 209, 166-181.  
9442878 D.J.Leahy (1997).
Implications of atomic-resolution structures for cell adhesion.
  Annu Rev Cell Dev Biol, 13, 363-393.  
9442880 F.S.Walsh, and P.Doherty (1997).
Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance.
  Annu Rev Cell Dev Biol, 13, 425-456.  
9395478 G.Chi-Rosso, P.J.Gotwals, J.Yang, L.Ling, K.Jiang, B.Chao, D.P.Baker, L.C.Burkly, S.E.Fawell, and V.E.Koteliansky (1997).
Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins.
  J Biol Chem, 272, 31447-31452.  
9095678 J.A.Carver, G.Esposito, P.Viglino, F.Fogolari, G.Guichard, J.P.Briand, M.H.Van Regenmortel, F.Brown, and P.Mascagni (1997).
Structural comparison between retro-inverso and parent peptides: molecular basis for the biological activity of a retro-inverso analogue of the immunodominant fragment of VP1 coat protein from foot-and-mouth disease virus.
  Biopolymers, 41, 569-590.  
9153268 J.C.Loftus, and R.C.Liddington (1997).
Cell adhesion in vascular biology. New insights into integrin-ligand interaction.
  J Clin Invest, 99, 2302-2306.  
9312081 J.V.Moyano, B.Carnemolla, C.Domínguez-Jiménez, M.García-Gila, J.P.Albar, P.Sánchez-Aparicio, A.Leprini, G.Querzé, L.Zardi, and A.Garcia-Pardo (1997).
Fibronectin type III5 repeat contains a novel cell adhesion sequence, KLDAPT, which binds activated alpha4beta1 and alpha4beta7 integrins.
  J Biol Chem, 272, 24832-24836.  
8999851 K.C.Ingham, S.A.Brew, S.Huff, and S.V.Litvinovich (1997).
Cryptic self-association sites in type III modules of fibronectin.
  J Biol Chem, 272, 1718-1724.  
9187659 K.Yamasaki, S.Naito, H.Anaguchi, T.Ohkubo, and Y.Ota (1997).
Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.
  Nat Struct Biol, 4, 498-504.
PDB codes: 1cto 1gcf
9260929 M.R.Taylor, J.R.Couto, C.D.Scallan, R.L.Ceriani, and J.A.Peterson (1997).
Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.
  DNA Cell Biol, 16, 861-869.  
9148805 M.S.Kellermayer, S.B.Smith, H.L.Granzier, and C.Bustamante (1997).
Folding-unfolding transitions in single titin molecules characterized with laser tweezers.
  Science, 276, 1112-1116.  
9261088 P.A.Carr, H.P.Erickson, and A.G.Palmer (1997).
Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin.
  Structure, 5, 949-959.  
9135136 P.L.Stewart, C.Y.Chiu, S.Huang, T.Muir, Y.Zhao, B.Chait, P.Mathias, and G.R.Nemerow (1997).
Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.
  EMBO J, 16, 1189-1198.  
9268674 P.Lanza, B.Felding-Habermann, Z.M.Ruggeri, M.Zanetti, and R.Billetta (1997).
Selective interaction of a conformationally-constrained Arg-Gly-Asp (RGD) motif with the integrin receptor alphavbeta3 expressed on human tumor cells.
  Blood Cells Mol Dis, 23, 230-241.  
9045628 R.P.Grant, C.Spitzfaden, H.Altroff, I.D.Campbell, and H.J.Mardon (1997).
Structural requirements for biological activity of the ninth and tenth FIII domains of human fibronectin.
  J Biol Chem, 272, 6159-6166.  
9171344 S.S.Hong, L.Karayan, J.Tournier, D.T.Curiel, and P.A.Boulanger (1997).
Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells.
  EMBO J, 16, 2294-2306.  
9150458 T.Sugimori, D.L.Griffith, and M.A.Arnaout (1997).
Emerging paradigms of integrin ligand binding and activation.
  Kidney Int, 51, 1454-1462.  
  8947027 A.Bateman, M.Jouet, J.MacFarlane, J.S.Du, S.Kenwrick, and C.Chothia (1996).
Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders.
  EMBO J, 15, 6050-6059.  
  8880920 A.Lombardo, Y.Wang, C.Z.Ni, X.Dai, C.D.Dickinson, R.Kodandapani, S.Chiang, C.A.White, F.Pio, N.H.Xuong, R.C.Hamlin, E.Ruoslahti, and K.R.Ely (1996).
Conformational flexibility and crystallization of tandemly linked type III modules of human fibronectin.
  Protein Sci, 5, 1934-1938.  
8548820 D.J.Leahy, I.Aukhil, and H.P.Erickson (1996).
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
  Cell, 84, 155-164.
PDB code: 1fnf
8970741 E.Ruoslahti (1996).
RGD and other recognition sequences for integrins.
  Annu Rev Cell Dev Biol, 12, 697-715.  
8939654 E.Y.Jones (1996).
Three-dimensional structure of cell adhesion molecules.
  Curr Opin Cell Biol, 8, 602-608.  
8973654 J.H.Viles, J.B.Mitchell, S.L.Gough, P.M.Doyle, C.J.Harris, P.J.Sadler, and J.M.Thornton (1996).
Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides.
  Eur J Biochem, 242, 352-362.  
8921253 J.Holm, R.Hillenbrand, V.Steuber, U.Bartsch, M.Moos, H.Lübbert, D.Montag, and M.Schachner (1996).
Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules.
  Eur J Neurosci, 8, 1613-1629.  
8617717 J.Krätzschmar, L.Lum, and C.P.Blobel (1996).
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
  J Biol Chem, 271, 4593-4596.  
8639264 J.R.Couto, M.R.Taylor, S.G.Godwin, R.L.Ceriani, and J.A.Peterson (1996).
Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain.
  DNA Cell Biol, 15, 281-286.  
8981327 J.R.Potts, and I.D.Campbell (1996).
Structure and function of fibronectin modules.
  Matrix Biol, 15, 313.  
8855243 K.W.Plaxco, C.Spitzfaden, I.D.Campbell, and C.M.Dobson (1996).
Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.
  Proc Natl Acad Sci U S A, 93, 10703-10706.  
8919879 P.A.McLenachan, P.J.Lockhart, H.R.Faber, and B.C.Mansfield (1996).
Evolutionary analysis of the multigene pregnancy-specific beta 1-glycoprotein family: separation of historical and nonhistorical signals.
  J Mol Evol, 42, 273-280.  
8870072 P.Bork, A.K.Downing, B.Kieffer, and I.D.Campbell (1996).
Structure and distribution of modules in extracellular proteins.
  Q Rev Biophys, 29, 119-167.  
8796911 P.Newham, and M.J.Humphries (1996).
Integrin adhesion receptors: structure, function and implications for biomedicine.
  Mol Med Today, 2, 304-313.  
8672453 P.Thiagarajan, A.J.Rippon, and D.H.Farrell (1996).
Alternative adhesion sites in human fibrinogen for vascular endothelial cells.
  Biochemistry, 35, 4169-4175.  
8922391 R.A.Lue, E.Brandin, E.P.Chan, and D.Branton (1996).
Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.
  J Cell Biol, 135, 1125-1137.  
8846226 B.Zhao, L.R.Helms, R.L.DesJarlais, S.S.Abdel-Meguid, and R.Wetzel (1995).
A paradigm for drug discovery using a conformation from the crystal structure of a presentation scaffold.
  Nat Struct Biol, 2, 1131-1137.  
8521488 C.Wu, V.M.Keivens, T.E.O'Toole, J.A.McDonald, and M.H.Ginsberg (1995).
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix.
  Cell, 83, 715-724.  
7552170 J.M.Bergelson, and M.E.Hemler (1995).
Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp?
  Curr Biol, 5, 615-617.  
  7896840 J.P.Jin (1995).
Cloned rat cardiac titin class I and class II motifs. Expression, purification, characterization, and interaction with F-actin.
  J Biol Chem, 270, 6908-6916.  
7534750 L.Blase, P.T.Daniel, K.Koretz, R.Schwartz-Albiez, and P.Möller (1995).
The capacity of human malignant B-lymphocytes to disseminate in SCID mice is correlated with functional expression of the fibronectin receptor alpha 5 beta 1 (CD49e/CD29).
  Int J Cancer, 60, 860-866.  
  8535243 L.R.Helms, and R.Wetzel (1995).
Destabilizing loop swaps in the CDRs of an immunoglobulin VL domain.
  Protein Sci, 4, 2073-2081.  
8557754 M.Ruppert, S.Aigner, M.Hubbe, H.Yagita, and P.Altevogt (1995).
The L1 adhesion molecule is a cellular ligand for VLA-5.
  J Cell Biol, 131, 1881-1891.  
7836460 R.Kodandapani, B.Veerapandian, T.J.Kunicki, and K.R.Ely (1995).
Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site.
  J Biol Chem, 270, 2268-2273.
PDB code: 1opg
7657703 R.Pasqualini, E.Koivunen, and E.Ruoslahti (1995).
A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins.
  J Cell Biol, 130, 1189-1196.  
14732167 R.R.Isberg, and G.T.Van Nhieu (1995).
The mechanism of phagocytic uptake promoted by invasin-integrin interaction.
  Trends Cell Biol, 5, 120-124.  
  7588601 S.S.Hong, and P.Boulanger (1995).
Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers.
  EMBO J, 14, 4714-4727.  
7629186 T.F.Busby, W.S.Argraves, S.A.Brew, I.Pechik, G.L.Gilliland, and K.C.Ingham (1995).
Heparin binding by fibronectin module III-13 involves six discontinuous basic residues brought together to form a cationic cradle.
  J Biol Chem, 270, 18558-18562.  
7542651 T.J.Kunicki, K.R.Ely, T.C.Kunicki, Y.Tomiyama, and D.S.Annis (1995).
The exchange of Arg-Gly-Asp (RGD) and Arg-Tyr-Asp (RYD) binding sequences in a recombinant murine Fab fragment specific for the integrin alpha IIb beta 3 does not alter integrin recognition.
  J Biol Chem, 270, 16660-16665.  
7890692 T.Yamada, H.Song, K.Inaka, Y.Shimada, M.Kikuchi, and M.Matsushima (1995).
Structure of a conformationally constrained Arg-Gly-Asp sequence inserted into human lysozyme.
  J Biol Chem, 270, 5687-5690.
PDB code: 1lmt
7615642 U.Nörenberg, M.Hubert, T.Brümmendorf, A.Tárnok, and F.G.Rathjen (1995).
Characterization of functional domains of the tenascin-R (restrictin) polypeptide: cell attachment site, binding with F11, and enhancement of F11-mediated neurite outgrowth by tenascin-R.
  J Cell Biol, 130, 473-484.  
7512815 A.H.Huber, Y.M.Wang, A.J.Bieber, and P.J.Bjorkman (1994).
Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A.
  Neuron, 12, 717-731.
PDB code: 1cfb
7937872 A.Ostman, Q.Yang, and N.K.Tonks (1994).
Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.
  Proc Natl Acad Sci U S A, 91, 9680-9684.  
8066086 D.J.Leahy, H.P.Erickson, I.Aukhil, P.Joshi, and W.A.Hendrickson (1994).
Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine.
  Proteins, 19, 48-54.  
7507494 E.Koivunen, B.Wang, and E.Ruoslahti (1994).
Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.
  J Cell Biol, 124, 373-380.  
7712288 G.Wagner, and D.F.Wyss (1994).
Cell surface adhesion receptors.
  Curr Opin Struct Biol, 4, 841-851.  
7937847 H.P.Erickson (1994).
Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.
  Proc Natl Acad Sci U S A, 91, 10114-10118.  
7764899 I.D.Campbell, and A.K.Downing (1994).
Building protein structure and function from modular units.
  Trends Biotechnol, 12, 168-172.  
8081748 I.D.Campbell, and C.Spitzfaden (1994).
Building proteins with fibronectin type III modules.
  Structure, 2, 333-337.  
14731666 K.Kühn, and J.Eble (1994).
The structural bases of integrin-ligand interactions.
  Trends Cell Biol, 4, 256-261.  
8191932 K.L.King, J.J.D'Anza, S.Bodary, R.Pitti, M.Siegel, R.A.Lazarus, M.S.Dennis, R.G.Hammonds, and S.C.Kukreja (1994).
Effects of kistrin on bone resorption in vitro and serum calcium in vivo.
  J Bone Miner Res, 9, 381-387.  
  7522724 M.Hensmann, G.W.Booker, G.Panayotou, J.Boyd, J.Linacre, M.Waterfield, and I.D.Campbell (1994).
Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study.
  Protein Sci, 3, 1020-1030.  
7813476 M.Jaseja, X.Lu, J.A.Williams, M.J.Sutcliffe, V.V.Kakkar, R.A.Parslow, and E.I.Hyde (1994).
1H-NMR assignments and secondary structure of dendroaspin, an RGD-containing glycoprotein IIb-IIIa (alpha IIb-beta 3) antagonist with a neurotoxin fold.
  Eur J Biochem, 226, 861-868.  
  8084019 P.Mathias, T.Wickham, M.Moore, and G.Nemerow (1994).
Multiple adenovirus serotypes use alpha v integrins for infection.
  J Virol, 68, 6811-6814.  
8127909 P.W.Mason, E.Rieder, and B.Baxt (1994).
RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathway.
  Proc Natl Acad Sci U S A, 91, 1932-1936.  
7980493 R.O.Hynes (1994).
The impact of molecular biology on models for cell adhesion.
  Bioessays, 16, 663-669.  
8081743 S.Lea, J.Hernández, W.Blakemore, E.Brocchi, S.Curry, E.Domingo, E.Fry, R.Abu-Ghazaleh, A.King, and J.Newman (1994).
The structure and antigenicity of a type C foot-and-mouth disease virus.
  Structure, 2, 123-139.
PDB code: 1fmd
  8207835 S.Valsesia-Wittmann, A.Drynda, G.Deléage, M.Aumailley, J.M.Heard, O.Danos, G.Verdier, and F.L.Cosset (1994).
Modifications in the binding domain of avian retrovirus envelope protein to redirect the host range of retroviral vectors.
  J Virol, 68, 4609-4619.  
15335785 C.B.Stewart (1993).
Protein modules: structural convergence and horizontal transfer?
  Curr Biol, 3, 158-160.  
8117416 D.S.Tuckwell, and M.J.Humphries (1993).
Molecular and cellular biology of integrins.
  Crit Rev Oncol Hematol, 15, 149-171.  
  8350395 M.Bai, B.Harfe, and P.Freimuth (1993).
Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells.
  J Virol, 67, 5198-5205.  
8357341 M.J.Humphries, A.P.Mould, and D.S.Tuckwell (1993).
Dynamic aspects of adhesion receptor function--integrins both twist and shout.
  Bioessays, 15, 391-397.  
  8223447 M.Zanetti, G.Filaci, R.H.Lee, P.del Guercio, F.Rossi, R.Bacchetta, F.Stevenson, V.Barnaba, and R.Billetta (1993).
Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif.
  EMBO J, 12, 4375-4384.  
  8358302 P.Bork, and R.F.Doolittle (1993).
Fibronectin type III modules in the receptor phosphatase CD45 and tapeworm antigens.
  Protein Sci, 2, 1185-1187.  
7763974 R.A.Lazarus, and R.S.McDowell (1993).
Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa.
  Curr Opin Biotechnol, 4, 438-445.  
8376980 T.Brümmendorf, and F.G.Rathjen (1993).
Axonal glycoproteins with immunoglobulin- and fibronectin type III-related domains in vertebrates: structural features, binding activities, and signal transduction.
  J Neurochem, 61, 1207-1219.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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