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Contents |
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* Residue conservation analysis
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PDB id:
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Transcription/DNA
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Title:
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Crystal structure of trp repressor operator complex at atomic resolution
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Structure:
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DNA (5'- d( Tp Gp Tp Ap Cp Tp Ap Gp Tp Tp Ap Ap Cp Tp Ap Gp T p Ap C)-3'). Chain: i, j, k, l. Engineered: yes. Protein (trp repressor). Chain: a, c, e, g
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Source:
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Synthetic: yes. Escherichia coli str. K12 substr.. Organism_taxid: 316407. Strain: w3110
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Biol. unit:
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Tetramer (from
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Resolution:
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Authors:
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Z.Otwinowski,R.W.Schevitz,R.-G.Zhang,C.L.Lawson,A.Joachimiak, R.Marmorstein,B.F.Luisi,P.B.Sigler
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Key ref:
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Z.Otwinowski
et al.
(1988).
Crystal structure of trp repressor/operator complex at atomic resolution.
Nature,
335,
321-329.
PubMed id:
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Date:
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30-Aug-92
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Release date:
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31-Jan-94
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PROCHECK
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Headers
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References
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Enzyme class:
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Chains A, C, E, G:
E.C.?
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Nature
335:321-329
(1988)
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PubMed id:
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Crystal structure of trp repressor/operator complex at atomic resolution.
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Z.Otwinowski,
R.W.Schevitz,
R.G.Zhang,
C.L.Lawson,
A.Joachimiak,
R.Q.Marmorstein,
B.F.Luisi,
P.B.Sigler.
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ABSTRACT
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The crystal structure of the trp repressor/operator complex shows an extensive
contact surface, including 24 direct and 6 solvent-mediated hydrogen bonds to
the phosphate groups of the DNA. There are no direct hydrogen bonds or non-polar
contacts to the bases that can explain the repressor's specificity for the
operator sequence. Rather, the sequence seems to be recognized indirectly
through its effects on the geometry of the phosphate backbone, which in turn
permits the formation of a stable interface. Water-mediated polar contacts to
the bases also appear to contribute part of the specificity.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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Where a reference describes a PDB structure, the PDB
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