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UniProt functional annotation for P00759 | ||
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| UniProt code: P00759. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen. |
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| Catalytic activity: | |
Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl- bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|- Xaa.; EC=3.4.21.35; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Subunit: | |
Monomer. |
| Tissue specificity: | |
Found in submaxillary gland. |
| Similarity: | |
Belongs to the peptidase S1 family. Kallikrein subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.