UniProt functional annotation for Q9HC62



	UniProt functional annotation for Q9HC62

UniProt code: Q9HC62.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000250|UniProtKB:Q9EQE1, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:21965678}.

Subunit: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1. {ECO:0000250, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:15296745, ECO:0000269|PubMed:21965678}.

Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12192048}. Nucleus membrane {ECO:0000269|PubMed:12192048}; Peripheral membrane protein {ECO:0000269|PubMed:12192048}; Nucleoplasmic side {ECO:0000269|PubMed:12192048}. Cytoplasm {ECO:0000269|PubMed:16738331}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:16738331}.

Domain: The N-terminus is necessary and sufficient for nuclear envelope targeting.

Ptm: Polyubiquitinated; which leads to proteasomal degradation. {ECO:0000269|PubMed:16738331}.

Similarity: Belongs to the peptidase C48 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). {ECO:0000250\|UniProtKB:Q91ZX6, ECO:0000250\|UniProtKB:Q9EQE1, ECO:0000269\|PubMed:11896061, ECO:0000269\|PubMed:12192048, ECO:0000269\|PubMed:20194620, ECO:0000269\|PubMed:21965678}.


Subunit:		Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1. {ECO:0000250, ECO:0000269\|PubMed:11896061, ECO:0000269\|PubMed:12192048, ECO:0000269\|PubMed:15296745, ECO:0000269\|PubMed:21965678}.
Subcellular location:		Nucleus, nuclear pore complex {ECO:0000269\|PubMed:12192048}. Nucleus membrane {ECO:0000269\|PubMed:12192048}; Peripheral membrane protein {ECO:0000269\|PubMed:12192048}; Nucleoplasmic side {ECO:0000269\|PubMed:12192048}. Cytoplasm {ECO:0000269\|PubMed:16738331}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269\|PubMed:16738331}.
Domain:		The N-terminus is necessary and sufficient for nuclear envelope targeting.
Ptm:		Polyubiquitinated; which leads to proteasomal degradation. {ECO:0000269\|PubMed:16738331}.
Similarity:		Belongs to the peptidase C48 family. {ECO:0000305}.