 |
PDBsum entry 1tf3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcription/DNA
|
PDB id
|
|
|
|
1tf3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Domain packing and dynamics in the DNA complex of the n-Terminal zinc fingers of tfiiia.
|
|
|
Authors
|
|
M.P.Foster,
D.S.Wuttke,
I.Radhakrishnan,
D.A.Case,
J.M.Gottesfeld,
P.E.Wright.
|
|
|
Ref.
|
|
Nat Struct Biol, 1997,
4,
605-608.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA
major groove. Substantial packing interfaces are formed between adjacent
fingers, the linkers lose their intrinsic flexibility upon DNA binding, and
several lysine side chains implicated in DNA recognition are dynamically
disordered.
|
|
|
Secondary reference #1
|
|
|
Title
|
|
Solution structure of the first three zinc fingers of tfiiia bound to the cognate DNA sequence: determinants of affinity and sequence specificity.
|
|
|
Authors
|
|
D.S.Wuttke,
M.P.Foster,
D.A.Case,
J.M.Gottesfeld,
P.E.Wright.
|
|
|
Ref.
|
|
J Mol Biol, 1997,
273,
183-206.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
perfect match.
|
|
|
|
|
|
|
|
|
|
|
|
Figure 5.
Figure 5. Distribution of intermole-
cular NOE restraints for (a) the
non-coding strand of the DNA, (b)
the coding strand of the DNA, and
(c) the protein.
|
|
Figure 12.
Figure 12. (a) Surface of each zinc finger domain buried
by packing interactions with the linkers. (b) Hydro-
phobic packing of the Thr38 methyl group into the
hydrophobic pocket formed by Phe17, His37, and
Leu34. The hydrogen bonds formed by Thr38 and Gly39
are shown as broken magenta lines.
|
|
|
|
|
|
The above figures are
reproduced from the cited reference
with permission from Elsevier
|
|
|
|
|
|
|
