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PDBsum entry 1tbg
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Complex (gtp-binding/transducer)
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PDB id
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1tbg
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of a g-Protein beta gamma dimer at 2.1a resolution.
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Authors
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J.Sondek,
A.Bohm,
D.G.Lambright,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1996,
379,
369-374.
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PubMed id
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Abstract
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Many signalling cascades use seven-helical transmembrane receptors coupled to
heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals
into intracellular responses. Upon nucleotide exchange catalysed by activated
receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta
gamma dimers, either of which can modulate many downstream effectors. Here we
use multiwavelength anomalous diffraction data to solve the crystal structure of
the beta gamma dimer of the G protein transducin. The beta-subunit is primarily
a seven-bladed beta-propeller that is partially encircled by an extended
gamma-subunit. The beta-propeller, which contains seven structurally similar WD
repeats, defines the stereochemistry of the WD repeat and the probable
architecture of all WD-repeat-containing domains. The structure details
interactions between G protein beta- and gamma-subunits and highlights regions
implicated in effector modulation for the conserved family of G protein beta
gamma dimers.
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Secondary reference #1
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Title
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The 2.0 a crystal structure of a heterotrimeric g protein.
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Authors
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D.G.Lambright,
J.Sondek,
A.Bohm,
N.P.Skiba,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1996,
379,
311-319.
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PubMed id
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Secondary reference #2
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Title
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Structural determinants for activation of the alpha-Subunit of a heterotrimeric g protein.
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Authors
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D.G.Lambright,
J.P.Noel,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1994,
369,
621-628.
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PubMed id
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Secondary reference #3
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Title
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Gtpase mechanism of gproteins from the 1.7-A crystal structure of transducin alpha-Gdp-Aif-4.
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Authors
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J.Sondek,
D.G.Lambright,
J.P.Noel,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1994,
372,
276-279.
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PubMed id
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Secondary reference #4
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Title
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The 2.2 a crystal structure of transducin-Alpha complexed with gtp gamma s.
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Authors
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J.P.Noel,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1993,
366,
654-663.
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PubMed id
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