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* Residue conservation analysis
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PDB id:
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| Name: |
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Complex (gtp-binding/transducer)
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Title:
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Beta-gamma dimer of the heterotrimeric g-protein transducin
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Structure:
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Transducin. Chain: a, b, c, d. Fragment: beta-1 subunit. Synonym: guanine nucleotide-binding protein g. Transducin. Chain: e, f, g, h. Fragment: gamma-1 subunit. Synonym: guanine nucleotide-binding protein g
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Source:
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Bos taurus. Cattle. Organism_taxid: 9913. Organ: eye. Tissue: retina. Cell: rod. Organelle: rod outer segment. Organelle: rod outer segment
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Biol. unit:
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Octamer (from
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Resolution:
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2.10Å
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R-factor:
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0.200
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R-free:
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0.306
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Authors:
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J.S.Sondek,A.Bohm,D.G.Lambright,H.E.Hamm,P.B.Sigler
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Key ref:
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J.Sondek
et al.
(1996).
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
Nature,
379,
369-374.
PubMed id:
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Date:
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15-Jun-96
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Release date:
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01-Apr-97
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PROCHECK
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Headers
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References
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Enzyme class:
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Chains A, E, B, F, C, G, D, H:
E.C.?
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Nature
379:369-374
(1996)
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PubMed id:
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Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
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J.Sondek,
A.Bohm,
D.G.Lambright,
H.E.Hamm,
P.B.Sigler.
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ABSTRACT
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Many signalling cascades use seven-helical transmembrane receptors coupled to
heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals
into intracellular responses. Upon nucleotide exchange catalysed by activated
receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta
gamma dimers, either of which can modulate many downstream effectors. Here we
use multiwavelength anomalous diffraction data to solve the crystal structure of
the beta gamma dimer of the G protein transducin. The beta-subunit is primarily
a seven-bladed beta-propeller that is partially encircled by an extended
gamma-subunit. The beta-propeller, which contains seven structurally similar WD
repeats, defines the stereochemistry of the WD repeat and the probable
architecture of all WD-repeat-containing domains. The structure details
interactions between G protein beta- and gamma-subunits and highlights regions
implicated in effector modulation for the conserved family of G protein beta
gamma dimers.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.V.Smrcka,
N.Kichik,
T.Tarragó,
M.Burroughs,
M.S.Park,
N.K.Itoga,
H.A.Stern,
B.M.Willardson,
and
E.Giralt
(2010).
NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.
|
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Proc Natl Acad Sci U S A,
107,
639-644.
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and
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(2010).
Structure of the measles virus hemagglutinin bound to the CD46 receptor.
|
| |
Nat Struct Mol Biol,
17,
124-129.
|
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PDB code:
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C.U.Stirnimann,
E.Petsalaki,
R.B.Russell,
and
C.W.Müller
(2010).
WD40 proteins propel cellular networks.
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| |
Trends Biochem Sci,
35,
565-574.
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J.Zhang,
W.Liu,
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C.Zhang,
and
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(2010).
G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion.
|
| |
Nat Commun,
1,
101.
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|
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|
K.A.Gonçalves,
J.C.Borges,
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I.L.Torriani,
and
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(2010).
Solution structure of the human signaling protein RACK1.
|
| |
BMC Struct Biol,
10,
15.
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R.Navarro-Olmos,
L.Kawasaki,
L.Domínguez-Ramírez,
L.Ongay-Larios,
R.Pérez-Molina,
and
R.Coria
(2010).
The beta subunit of the heterotrimeric G protein triggers the Kluyveromyces lactis pheromone response pathway in the absence of the gamma subunit.
|
| |
Mol Biol Cell,
21,
489-498.
|
|
|
|
|
|
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R.S.Demarco,
and
E.A.Lundquist
(2010).
RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration.
|
| |
PLoS Genet,
6,
e1001215.
|
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|
|
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|
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T.Mulligan,
H.Blaser,
E.Raz,
and
S.A.Farber
(2010).
Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish.
|
| |
Cell Signal,
22,
221-233.
|
|
|
|
|
|
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Z.L.Chi,
F.Yasumoto,
Y.Sergeev,
M.Minami,
M.Obazawa,
I.Kimura,
Y.Takada,
and
T.Iwata
(2010).
Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice.
|
| |
Hum Mol Genet,
19,
3806-3815.
|
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|
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D.J.Dupré,
M.Robitaille,
R.V.Rebois,
and
T.E.Hébert
(2009).
The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.
|
| |
Annu Rev Pharmacol Toxicol,
49,
31-56.
|
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|
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E.J.Heenan,
J.L.Vanhooke,
B.R.Temple,
L.Betts,
J.E.Sondek,
and
H.G.Dohlman
(2009).
Structure and function of Vps15 in the endosomal G protein signaling pathway.
|
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Biochemistry,
48,
6390-6401.
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PDB code:
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W.Baehr,
and
J.M.Frederick
(2009).
Naturally occurring animal models with outer retina phenotypes.
|
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Vision Res,
49,
2636-2652.
|
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|
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W.E.McIntire
(2009).
Structural determinants involved in the formation and activation of G protein betagamma dimers.
|
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Neurosignals,
17,
82-99.
|
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|
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A.M.Preininger,
J.Parello,
S.M.Meier,
G.Liao,
and
H.E.Hamm
(2008).
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.
|
| |
Biochemistry,
47,
10281-10293.
|
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|
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|
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A.R.Zurita,
and
L.Birnbaumer
(2008).
The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.
|
| |
Proc Natl Acad Sci U S A,
105,
2363-2368.
|
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|
|
|
|
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A.V.Smrcka
(2008).
G protein betagamma subunits: central mediators of G protein-coupled receptor signaling.
|
| |
Cell Mol Life Sci,
65,
2191-2214.
|
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|
|
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|
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A.V.Smrcka,
D.M.Lehmann,
and
A.L.Dessal
(2008).
G protein betagamma subunits as targets for small molecule therapeutic development.
|
| |
Comb Chem High Throughput Screen,
11,
382-395.
|
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|
|
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|
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D.Rakotobe,
S.Violot,
S.S.Hong,
P.Gouet,
and
P.Boulanger
(2008).
Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.
|
| |
Virol J,
5,
32.
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|
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|
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E.Kloss,
N.Courtemanche,
and
D.Barrick
(2008).
Repeat-protein folding: new insights into origins of cooperativity, stability, and topology.
|
| |
Arch Biochem Biophys,
469,
83-99.
|
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|
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|
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H.Ullah,
E.L.Scappini,
A.F.Moon,
L.V.Williams,
D.L.Armstrong,
and
L.C.Pedersen
(2008).
Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
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| |
Protein Sci,
17,
1771-1780.
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PDB code:
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J.J.Song,
J.D.Garlick,
and
R.E.Kingston
(2008).
Structural basis of histone H4 recognition by p55.
|
| |
Genes Dev,
22,
1313-1318.
|
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PDB codes:
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M.Buscarlet,
A.Perin,
A.Laing,
J.M.Brickman,
and
S.Stifani
(2008).
Inhibition of Cortical Neuron Differentiation by Groucho/TLE1 Requires Interaction with WRPW, but Not Eh1, Repressor Peptides.
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| |
J Biol Chem,
283,
24881-24888.
|
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|
|
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|
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M.L.Cheever,
J.T.Snyder,
S.Gershburg,
D.P.Siderovski,
T.K.Harden,
and
J.Sondek
(2008).
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
|
| |
Nat Struct Mol Biol,
15,
155-162.
|
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PDB code:
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R.Ohgaki,
N.Fukura,
M.Matsushita,
K.Mitsui,
and
H.Kanazawa
(2008).
Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.
|
| |
J Biol Chem,
283,
4417-4429.
|
|
|
|
|
|
|
S.C.Strickfaden,
and
P.M.Pryciak
(2008).
Distinct Roles for Two G{alpha} G Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein.
|
| |
Mol Biol Cell,
19,
181-197.
|
|
|
|
|
|
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S.Chen,
F.Lin,
M.E.Shin,
F.Wang,
L.Shen,
and
H.E.Hamm
(2008).
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma.
|
| |
Mol Biol Cell,
19,
3909-3922.
|
|
|
|
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|
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T.R.Hynes,
E.Yost,
S.Mervine,
and
C.H.Berlot
(2008).
Multicolor BiFC analysis of competition among G protein beta and gamma subunit interactions.
|
| |
Methods,
45,
207-213.
|
|
|
|
|
|
|
W.M.Oldham,
and
H.E.Hamm
(2008).
Heterotrimeric G protein activation by G-protein-coupled receptors.
|
| |
Nat Rev Mol Cell Biol,
9,
60-71.
|
|
|
|
|
|
|
B.R.Temple,
and
A.M.Jones
(2007).
The plant heterotrimeric G-protein complex.
|
| |
Annu Rev Plant Biol,
58,
249-266.
|
|
|
|
|
|
|
C.E.Zeller,
S.C.Parnell,
and
H.G.Dohlman
(2007).
The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast.
|
| |
J Biol Chem,
282,
25168-25176.
|
|
|
|
|
|
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F.Mancia,
and
W.A.Hendrickson
(2007).
Expression of recombinant G-protein coupled receptors for structural biology.
|
| |
Mol Biosyst,
3,
723-734.
|
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|
|
|
|
|
G.Drin,
and
S.Scarlata
(2007).
Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme?
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| |
Cell Signal,
19,
1383-1392.
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|
|
J.Napetschnig,
G.Blobel,
and
A.Hoelz
(2007).
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.
|
| |
Proc Natl Acad Sci U S A,
104,
1783-1788.
|
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PDB code:
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L.Vogeley,
V.D.Trivedi,
O.A.Sineshchekov,
E.N.Spudich,
J.L.Spudich,
and
H.Luecke
(2007).
Crystal structure of the Anabaena sensory rhodopsin transducer.
|
| |
J Mol Biol,
367,
741-751.
|
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PDB codes:
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M.Jaffé,
and
J.Bubis
(2007).
Use of 5'-[p-(fluorosulfonyl)benzoyl] guanosine as an affinity probe for the guanine nucleotide-binding site of transducin.
|
| |
Protein J,
26,
125-133.
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M.Tanaka-Kunishima,
Y.Ishida,
K.Takahashi,
M.Honda,
and
T.Oonuma
(2007).
Ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family.
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| |
BMC Evol Biol,
7,
143.
|
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P.S.Crozier,
M.J.Stevens,
and
T.B.Woolf
(2007).
How a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations.
|
| |
Proteins,
66,
559-574.
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|
R.L.Dedrick
(2007).
Understanding gene expression patterns in immune-mediated disorders.
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| |
J Immunotoxicol,
4,
201-207.
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R.Maggio,
G.Innamorati,
and
M.Parenti
(2007).
G protein-coupled receptor oligomerization provides the framework for signal discrimination.
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| |
J Neurochem,
103,
1741-1752.
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S.A.Denslow,
and
P.A.Wade
(2007).
The human Mi-2/NuRD complex and gene regulation.
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| |
Oncogene,
26,
5433-5438.
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S.M.Hanson,
E.V.Gurevich,
S.A.Vishnivetskiy,
M.R.Ahmed,
X.Song,
and
V.V.Gurevich
(2007).
Each rhodopsin molecule binds its own arrestin.
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| |
Proc Natl Acad Sci U S A,
104,
3125-3128.
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T.Fritzius,
A.D.Frey,
M.Schweneker,
D.Mayer,
and
K.Moelling
(2007).
WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.
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| |
FEBS J,
274,
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V.Srinivasan,
D.J.Netz,
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A.J.Pierik,
H.Michel,
and
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(2007).
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.
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| |
Structure,
15,
1246-1257.
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PDB code:
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X.Xie,
Z.Wang,
and
Y.Chen
(2007).
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
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| |
Mol Cell Biochem,
301,
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Y.Marrari,
M.Crouthamel,
R.Irannejad,
and
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(2007).
Assembly and trafficking of heterotrimeric G proteins.
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Biochemistry,
46,
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|
Z.Han,
X.Xing,
M.Hu,
Y.Zhang,
P.Liu,
and
J.Chai
(2007).
Structural basis of EZH2 recognition by EED.
|
| |
Structure,
15,
1306-1315.
|
|
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PDB code:
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|
|
C.Chen,
L.Li,
and
Y.Xiao
(2006).
Identification of key residues in proteins by using their physical characters.
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Phys Rev E Stat Nonlin Soft Matter Phys,
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D.A.Palmer,
J.K.Thompson,
L.Li,
A.Prat,
and
P.Wang
(2006).
Gib2, a novel Gbeta-like/RACK1 homolog, functions as a Gbeta subunit in cAMP signaling and is essential in Cryptococcus neoformans.
|
| |
J Biol Chem,
281,
32596-32605.
|
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|
E.H.Sklan,
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and
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(2006).
RACK1 has the nerve to act: structure meets function in the nervous system.
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| |
Prog Neurobiol,
78,
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F.C.Nery,
G.C.Bressan,
M.R.Alborghetti,
D.O.Passos,
T.M.Kuniyoshi,
C.H.Ramos,
S.Oyama,
and
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(2006).
A spectroscopic analysis of the interaction between the human regulatory proteins RACK1 and Ki-1/57.
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| |
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387,
577-582.
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and
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Heterotrimeric G-proteins: a short history.
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| |
Br J Pharmacol,
147,
S46-S55.
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J.E.Slessareva,
S.M.Routt,
B.Temple,
V.A.Bankaitis,
and
H.G.Dohlman
(2006).
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.
|
| |
Cell,
126,
191-203.
|
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|
K.D.Ridge,
N.G.Abdulaev,
C.Zhang,
T.Ngo,
D.M.Brabazon,
and
J.P.Marino
(2006).
Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states.
|
| |
J Biol Chem,
281,
7635-7648.
|
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|
|
|
|
M.Akgoz,
V.Kalyanaraman,
and
N.Gautam
(2006).
G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction.
|
| |
Cell Signal,
18,
1758-1768.
|
|
|
|
|
|
|
M.Waragai,
S.Nagamitsu,
W.Xu,
Y.J.Li,
X.Lin,
and
T.Ashizawa
(2006).
Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.
|
| |
J Neurosci Res,
83,
1170-1178.
|
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|
R.Coria,
L.Kawasaki,
F.Torres-Quiroz,
L.Ongay-Larios,
E.Sánchez-Paredes,
N.Velázquez-Zavala,
R.Navarro-Olmos,
M.Rodríguez-González,
R.Aguilar-Corachán,
and
G.Coello
(2006).
The pheromone response pathway of Kluyveromyces lactis.
|
| |
FEMS Yeast Res,
6,
336-344.
|
|
|
|
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|
R.D.Busam,
A.G.Thorsell,
A.Flores,
M.Hammarström,
C.Persson,
and
B.M.Hallberg
(2006).
First structure of a eukaryotic phosphohistidine phosphatase.
|
| |
J Biol Chem,
281,
33830-33834.
|
|
|
PDB code:
|
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|
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|
|
S.A.Chasse,
P.Flanary,
S.C.Parnell,
N.Hao,
J.Y.Cha,
D.P.Siderovski,
and
H.G.Dohlman
(2006).
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
|
| |
Eukaryot Cell,
5,
330-346.
|
|
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|
|
|
S.E.Haydel,
and
J.E.Clark-Curtiss
(2006).
The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed beta-propeller.
|
| |
J Bacteriol,
188,
150-159.
|
|
|
|
|
|
|
S.Gaillard,
Y.Bailly,
M.Benoist,
T.Rakitina,
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