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UniProt functional annotation for Q01064 | ||
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| UniProt code: Q01064. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269|PubMed:15260978}. |
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| Catalytic activity: | |
Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:15260978}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:15260978}; |
| Activity regulation: | |
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). |
| Subunit: | |
Homodimer. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.