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UniProt functional annotation for P63249 | ||
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| UniProt codes: P63249, P27776. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
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| Tissue specificity: | |
Highest expression in muscle (both skeletal and cardiac) and brain. |
| Miscellaneous: | |
The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site (By similarity). {ECO:0000250}. |
| Similarity: | |
Belongs to the PKI family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.