UniProt functional annotation for P32790



	UniProt functional annotation for P32790

UniProt code: P32790.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. {ECO:0000269|PubMed:10198057, ECO:0000269|PubMed:10594004, ECO:0000269|PubMed:11940605, ECO:0000269|PubMed:11950888, ECO:0000269|PubMed:12237851, ECO:0000269|PubMed:12388763, ECO:0000269|PubMed:12734398, ECO:0000269|PubMed:12814545, ECO:0000269|PubMed:14761940, ECO:0000269|PubMed:15525671, ECO:0000269|PubMed:17286805, ECO:0000269|PubMed:8335689, ECO:0000269|PubMed:8756649, ECO:0000269|PubMed:9008707, ECO:0000269|PubMed:9128251}.

Subunit: Component of the PAN1 actin cytoskeleton-regulatory complex. Interacts with ABP1, KRE6, LAS17, LSB5, RSP5, RVS167, VPS1 and YSC84. {ECO:0000269|PubMed:10594004, ECO:0000269|PubMed:11739778, ECO:0000269|PubMed:11950888, ECO:0000269|PubMed:12237851, ECO:0000269|PubMed:12388763, ECO:0000269|PubMed:12734398, ECO:0000269|PubMed:14761940, ECO:0000269|PubMed:15265985, ECO:0000269|PubMed:15651983, ECO:0000269|PubMed:9024694}.

Subcellular location: Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches. Is associated with cortical actin patches in its dephosphorylated form and dissociates upon phosphorylation by PRK1.

Ptm: Phosphorylated by PRK1. {ECO:0000269|PubMed:11739778, ECO:0000269|PubMed:17978096}.

Miscellaneous: Present with 952 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the SLA1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. {ECO:0000269\|PubMed:10198057, ECO:0000269\|PubMed:10594004, ECO:0000269\|PubMed:11940605, ECO:0000269\|PubMed:11950888, ECO:0000269\|PubMed:12237851, ECO:0000269\|PubMed:12388763, ECO:0000269\|PubMed:12734398, ECO:0000269\|PubMed:12814545, ECO:0000269\|PubMed:14761940, ECO:0000269\|PubMed:15525671, ECO:0000269\|PubMed:17286805, ECO:0000269\|PubMed:8335689, ECO:0000269\|PubMed:8756649, ECO:0000269\|PubMed:9008707, ECO:0000269\|PubMed:9128251}.


Subunit:		Component of the PAN1 actin cytoskeleton-regulatory complex. Interacts with ABP1, KRE6, LAS17, LSB5, RSP5, RVS167, VPS1 and YSC84. {ECO:0000269\|PubMed:10594004, ECO:0000269\|PubMed:11739778, ECO:0000269\|PubMed:11950888, ECO:0000269\|PubMed:12237851, ECO:0000269\|PubMed:12388763, ECO:0000269\|PubMed:12734398, ECO:0000269\|PubMed:14761940, ECO:0000269\|PubMed:15265985, ECO:0000269\|PubMed:15651983, ECO:0000269\|PubMed:9024694}.
Subcellular location:		Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches. Is associated with cortical actin patches in its dephosphorylated form and dissociates upon phosphorylation by PRK1.
Ptm:		Phosphorylated by PRK1. {ECO:0000269\|PubMed:11739778, ECO:0000269\|PubMed:17978096}.
Miscellaneous:		Present with 952 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the SLA1 family. {ECO:0000305}.