PDBsum entry 1srs

Transcription/DNA

PDB id: 1srs

Contents

Protein chains

84 a.a. *

80 a.a. *

DNA/RNA

* Residue conservation analysis

References listed in PDB file

Key reference

• Title: Structure of serum response factor core bound to DNA.
• Authors: L.Pellegrini, S.Tan, T.J.Richmond.
• Ref.: Nature, 1995, 376, 490-498.
• PubMed id: 7637780

Abstract

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.