UniProt functional annotation for Q02793



	UniProt functional annotation for Q02793

UniProt code: Q02793.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology. {ECO:0000269|PubMed:10744028, ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:11720286, ECO:0000269|PubMed:14671320, ECO:0000269|PubMed:14992724, ECO:0000269|PubMed:15044957, ECO:0000269|PubMed:16816949, ECO:0000269|PubMed:3029964, ECO:0000269|PubMed:6371496, ECO:0000269|PubMed:7739557, ECO:0000269|PubMed:9258672, ECO:0000269|PubMed:9482746}.

Subunit: Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation. {ECO:0000269|PubMed:10744028, ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:14992724, ECO:0000269|PubMed:16816949}.

Subcellular location: Cytoplasm. Nucleus. Chromosome. Note=Relocalizes from the cytoplasm to the nucleus and is recruited to chromosomes by SPO11 during meiotic prophase.

Miscellaneous: Present with 1710 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology. {ECO:0000269\|PubMed:10744028, ECO:0000269\|PubMed:11532933, ECO:0000269\|PubMed:11720286, ECO:0000269\|PubMed:14671320, ECO:0000269\|PubMed:14992724, ECO:0000269\|PubMed:15044957, ECO:0000269\|PubMed:16816949, ECO:0000269\|PubMed:3029964, ECO:0000269\|PubMed:6371496, ECO:0000269\|PubMed:7739557, ECO:0000269\|PubMed:9258672, ECO:0000269\|PubMed:9482746}.


Subunit:		Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation. {ECO:0000269\|PubMed:10744028, ECO:0000269\|PubMed:11532933, ECO:0000269\|PubMed:14992724, ECO:0000269\|PubMed:16816949}.
Subcellular location:		Cytoplasm. Nucleus. Chromosome. Note=Relocalizes from the cytoplasm to the nucleus and is recruited to chromosomes by SPO11 during meiotic prophase.
Miscellaneous:		Present with 1710 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.