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UniProt functional annotation for Q9DBJ3 | ||
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| UniProt code: Q9DBJ3. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). {ECO:0000250}. |
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| Subunit: | |
Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. {ECO:0000250}. |
| Tissue specificity: | |
Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level). {ECO:0000269|PubMed:17430976}. |
| Domain: | |
The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity). {ECO:0000250}. |
| Ptm: | |
Phosphorylated on tyrosine in response to insulin. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.