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UniProt functional annotation for Q13370 | ||
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| UniProt code: Q13370. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}. |
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| Catalytic activity: | |
Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:15147193}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:15147193}; |
| Activity regulation: | |
Inhibited by cGMP. |
| Subunit: | |
Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6. {ECO:0000250, ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue specificity: | |
Abundant in adipose tissues. |
| Similarity: | |
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.