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PDBsum entry 1slc
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Complex(lectin/saccharide)
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PDB id
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1slc
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.
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Authors
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Y.Bourne,
B.Bolgiano,
D.I.Liao,
G.Strecker,
P.Cantau,
O.Herzberg,
T.Feizi,
C.Cambillau.
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Ref.
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Nat Struct Biol, 1994,
1,
863-870.
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
percentage match of
77%.
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Abstract
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Galectins are beta-galactoside-binding proteins that occur intra- and
extracellularly in many animal tissues. They have been proposed to form networks
of glycoconjugates on the cell surface, where they may modulate various cell
response pathways such as growth, activation and adhesion. The high resolution
X-ray crystallographic analyses of three crystal forms of bovine galectin-1 in
complex with biantennary saccharides of N-acetyllactosamine type reveal infinite
chains of lectin dimers cross-linked through N-acetyllactosamine units located
at the end of the oligosaccharide antenna. The oligosaccharide adopts a
different low energy conformation in each of the three crystal forms.
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Secondary reference #1
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Title
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Crystallization and preliminary X-Ray diffraction studies of the soluble 14 kda beta-Galactoside-Binding lectin from bovine heart.
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Authors
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Y.Bourne,
B.Bolgiano,
M.P.Nésa,
P.Penfold,
D.Johnson,
T.Feizi,
C.Cambillau.
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Ref.
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J Mol Biol, 1994,
235,
787-789.
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PubMed id
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