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PDBsum entry 1shc
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Complex (signal transduction/peptide)
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PDB id
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1shc
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Structure and ligand recognition of the phosphotyrosine binding domain of shc.
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Authors
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M.M.Zhou,
K.S.Ravichandran,
E.F.Olejniczak,
A.M.Petros,
R.P.Meadows,
M.Sattler,
J.E.Harlan,
W.S.Wade,
S.J.Burakoff,
S.W.Fesik.
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Ref.
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Nature, 1995,
378,
584-592.
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PubMed id
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Abstract
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The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB)
domain of Shc complexed to a phosphopeptide reveals an alternative means of
recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the
phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the
protein, interacts with a hydrophobic pocket through the (pY-5) residue, and
adopts a beta-turn. The PTB domain is structurally similar to pleckstrin
homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic
phospholipids, suggesting a possible role in membrane localization.
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Secondary reference #1
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Title
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Structural basis for il-4 receptor phosphopeptide recognition by the irs-1 ptb domain.
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Authors
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M.M.Zhou,
B.Huang,
E.T.Olejniczak,
R.P.Meadows,
S.B.Shuker,
M.Miyazaki,
T.Trüb,
S.E.Shoelson,
S.W.Fesik.
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Ref.
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Nat Struct Biol, 1996,
3,
388-393.
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PubMed id
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Secondary reference #2
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Title
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Specificity of the ptb domain of shc for beta turn-Forming pentapeptide motifs amino-Terminal to phosphotyrosine.
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Authors
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T.Trüb,
W.E.Choi,
G.Wolf,
E.Ottinger,
Y.Chen,
M.Weiss,
S.E.Shoelson.
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Ref.
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J Biol Chem, 1995,
270,
18205-18208.
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PubMed id
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Secondary reference #3
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Title
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An alternative to sh2 domains for binding tyrosine-Phosphorylated proteins.
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Authors
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W.M.Kavanaugh,
L.T.Williams.
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Ref.
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Science, 1994,
266,
1862-1865.
[DOI no: ]
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PubMed id
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