 |
PDBsum entry 1shb
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Phosphotransferase
|
PDB id
|
|
|
|
1shb
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Crystal structure of the phosphotyrosine recognition domain sh2 of V-Src complexed with tyrosine-Phosphorylated peptides.
|
|
|
Authors
|
|
G.Waksman,
D.Kominos,
S.C.Robertson,
N.Pant,
D.Baltimore,
R.B.Birge,
D.Cowburn,
H.Hanafusa,
B.J.Mayer,
M.Overduin,
M.D.Resh,
C.B.Rios,
L.Silverman,
J.Kuriyan.
|
|
|
Ref.
|
|
Nature, 1992,
358,
646-653.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Three-dimensional structures of complexes of the SH2 domain of the v-src
oncogene product with two phosphotyrosyl peptides have been determined by X-ray
crystallography at resolutions of 1.5 and 2.0 A, respectively. A central
antiparallel beta-sheet in the structure is flanked by two alpha-helices, with
peptide binding mediated by the sheet, intervening loops and one of the helices.
The specific recognition of phosphotyrosine involves amino-aromatic interactions
between lysine and arginine side chains and the ring system in addition to
hydrogen-bonding interactions with the phosphate.
|
|
|
|
|
|
|
