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UniProt functional annotation for Q70ET3 | ||
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| UniProt code: Q70ET3. |
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| Organism: | |
Norwalk virus. |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Caliciviridae; Norovirus. |
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| Function: | |
3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation. {ECO:0000256|PROSITE-ProRule:PRU00870}. |
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| Catalytic activity: | |
Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=3.4.22.66; Evidence={ECO:0000256|PROSITE- ProRule:PRU00870}; |
| Catalytic activity: | |
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence={ECO:0000256|ARBA:ARBA00001491}; |
| Ptm: | |
Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein. {ECO:0000256|PROSITE-ProRule:PRU00870}. |
Annotations taken from UniProtKB at the EBI.