PDBsum entry 1seb

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Complex (mhc ii/peptide/toxin) PDB id
Protein chains
181 a.a. *
192 a.a. *
13 a.a. *
206 a.a. *
* Residue conservation analysis

References listed in PDB file
Key reference
Title Three-Dimensional structure of a human class ii histocompatibility molecule complexed with superantigen.
Authors T.S.Jardetzky, J.H.Brown, J.C.Gorga, L.J.Stern, R.G.Urban, Y.I.Chi, C.Stauffacher, J.L.Strominger, D.C.Wiley.
Ref. Nature, 1994, 368, 711-718.
PubMed id 8152483
The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has been determined by X-ray crystallography. The superantigen binds as an intact protein outside the conventional peptide antigen-binding site of the class II major histocompatibility complex (MHC) molecule. No large conformational changes occur upon complex formation in either the DR1 or the enterotoxin B molecules. The structure of the complex helps explain how different class II molecules and superantigens associate and suggests a model for ternary complex formation with the T-cell antigen receptor (TCR), in which unconventional TCR-MHC contacts are possible.
Secondary reference #1
Title Crystallographic analysis of endogenous peptides associated with hla-Dr1 suggests a common, Polyproline ii-Like conformation for bound peptides.
Authors T.S.Jardetzky, J.H.Brown, J.C.Gorga, L.J.Stern, R.G.Urban, J.L.Strominger, D.C.Wiley.
Ref. Proc Natl Acad Sci U S A, 1996, 93, 734-738.
PubMed id 8570625
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