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UniProt functional annotation for P81397 | ||
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| UniProt code: P81397. |
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| Organism: | |
Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Calloselasma. |
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| Function: | |
Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity. {ECO:0000269|PubMed:10360956, ECO:0000269|PubMed:11121411, ECO:0000269|PubMed:12871211}. |
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| Subunit: | |
Heterotetramer of subunit alpha, beta, gamma and delta; only the gamma and the delta subunits are disulfide-linked. Alpha-beta heterodimer and gamma-delta heterodimer associate orthogonally, giving a cruciform conformation (PubMed:19369383). This heterotetramer may covalently dimerizes thanks to the gamma subunit (PubMed:11121411). {ECO:0000269|PubMed:11121411, ECO:0000269|PubMed:15576563, ECO:0000269|PubMed:19369383}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Mass spectrometry: | |
Mass=15955.90; Mass_error=1.44; Method=Electrospray; Evidence={ECO:0000269|PubMed:10360956}; |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.