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UniProt functional annotation for P26811 | ||
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| UniProt code: P26811. |
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| Organism: | |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus. |
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| Function: | |
This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. {ECO:0000269|PubMed:12535540}. |
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| Catalytic activity: | |
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; |
| Activity regulation: | |
DNA synthesis is stimulated by PCNA heterotrimers. {ECO:0000269|PubMed:12535540}. |
| Subunit: | |
Interacts with PCNA subunit PCNA2 and weakly with PCNA3. {ECO:0000269|PubMed:12535540}. |
| Similarity: | |
Belongs to the DNA polymerase type-B family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.