UniProt functional annotation for P0A333

UniProt codes: P0A333, Q54397.

Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
Taxonomy: Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
 
Function: Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. {ECO:0000250}.
 
Subunit: Homotetramer. {ECO:0000250}.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Domain: The cytoplasmic C-terminus is involved in the gating mechanism. {ECO:0000250}.
Miscellaneous: The amino acids 62-79 are situated in the membrane and are important for channel structure and properties. {ECO:0000250}.
Similarity: Belongs to the potassium channel family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.