UniProt functional annotation for Q9UGP5

UniProt code: Q9UGP5.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. {ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:15537631}.
Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Cofactor: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Subunit: Binds PCNA. {ECO:0000269|PubMed:14992725}.
Subcellular location: Nucleus.
Tissue specificity: Expressed in a number of tissues. Abundant in testis.
Similarity: Belongs to the DNA polymerase type-X family. {ECO:0000305}.
Similarity: Contains 1 BRCT domain. {ECO:0000255|PROSITE- ProRule:PRU00033}.
Sequence caution: Sequence=BAB14050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.