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PDBsum entry 1rsy
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Calcium/phospholipid binding protein
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PDB id
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1rsy
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References listed in PDB file
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Key reference
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Title
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Structure of the first c2 domain of synaptotagmin i: a novel ca2+/phospholipid-Binding fold.
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Authors
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R.B.Sutton,
B.A.Davletov,
A.M.Berghuis,
T.C.Südhof,
S.R.Sprang.
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Ref.
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Cell, 1995,
80,
929-938.
[DOI no: ]
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PubMed id
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Abstract
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C2 domains are regulatory sequence motifs that occur widely in nature.
Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of
exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor.
We now describe the three-dimensional structure of this C2 domain at 1.9 A
resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide
forms an eight-stranded beta sandwich constructed around a conserved
four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped
depression between two polypeptide loops located at the N- and C-termini of the
C2-key motif.
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Secondary reference #1
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Title
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A single c2 domain from synaptotagmin i is sufficient for high affinity ca2+/phospholipid binding.
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Authors
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B.A.Davletov,
T.C.Südhof.
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Ref.
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J Biol Chem, 1993,
268,
26386-26390.
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PubMed id
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