UniProt functional annotation for P78310



	UniProt functional annotation for P78310

UniProt code: P78310.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.

Function: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.

Function: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.

Subunit: Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12468544, ECO:0000269|PubMed:15304526, ECO:0000269|PubMed:15364909, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666}.

Subunit: (Microbial infection) Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins (PubMed:14978041, PubMed:9733828, PubMed:10666333, PubMed:10814575, PubMed:12297051, PubMed:10567268). {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:14978041, ECO:0000269|PubMed:9733828}.

Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12021372, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15364909}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12297051}.

Subcellular location: [Isoform 3]: Secreted {ECO:0000269|PubMed:14978041}.

Subcellular location: [Isoform 4]: Secreted {ECO:0000269|PubMed:14978041}.

Subcellular location: [Isoform 5]: Secreted {ECO:0000269|PubMed:14978041}.

Tissue specificity: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.

Domain: The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.

Domain: The PDZ-binding motif mediates interaction with MPDZ and MAGI1.

Ptm: N-glycosylated. {ECO:0000250}.

Ptm: Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000269|PubMed:12021372}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269\|PubMed:11734628, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:15800062, ECO:0000269\|PubMed:19064666, ECO:0000269\|PubMed:9096397}.



Function:		(Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269\|PubMed:10567268, ECO:0000269\|PubMed:10666333, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:9733828}.



Function:		(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269\|PubMed:10814575, ECO:0000269\|PubMed:14978041}.


Subunit:		Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. {ECO:0000269\|PubMed:11734628, ECO:0000269\|PubMed:12468544, ECO:0000269\|PubMed:15304526, ECO:0000269\|PubMed:15364909, ECO:0000269\|PubMed:15800062, ECO:0000269\|PubMed:19064666}.
Subunit:		(Microbial infection) Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins (PubMed:14978041, PubMed:9733828, PubMed:10666333, PubMed:10814575, PubMed:12297051, PubMed:10567268). {ECO:0000269\|PubMed:10567268, ECO:0000269\|PubMed:10666333, ECO:0000269\|PubMed:10814575, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:14978041, ECO:0000269\|PubMed:9733828}.
Subcellular location:		[Isoform 1]: Cell membrane {ECO:0000269\|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269\|PubMed:11316797, ECO:0000269\|PubMed:12021372, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:15364909}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269\|PubMed:11734628, ECO:0000269\|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269\|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269\|PubMed:11316797, ECO:0000269\|PubMed:12297051}.
Subcellular location:		[Isoform 3]: Secreted {ECO:0000269\|PubMed:14978041}.
Subcellular location:		[Isoform 4]: Secreted {ECO:0000269\|PubMed:14978041}.
Subcellular location:		[Isoform 5]: Secreted {ECO:0000269\|PubMed:14978041}.
Tissue specificity:		Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269\|PubMed:10490761, ECO:0000269\|PubMed:11457744, ECO:0000269\|PubMed:11549277, ECO:0000269\|PubMed:9096397}.
Domain:		The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.
Domain:		The PDZ-binding motif mediates interaction with MPDZ and MAGI1.
Ptm:		N-glycosylated. {ECO:0000250}.
Ptm:		Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000269\|PubMed:12021372}.