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PDBsum entry 1rsf
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Signaling protein
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PDB id
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1rsf
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Solution structure of the coxsackievirus and adenovirus receptor domain 1.
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Authors
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S.Jiang,
A.Jacobs,
T.M.Laue,
M.Caffrey.
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Ref.
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Biochemistry, 2004,
43,
1847-1853.
[DOI no: ]
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PubMed id
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Abstract
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of
coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function of CAR,
which is expressed in a wide variety of tissue types, is thought to involve
homophilic cell adhesion in the developing brain. The extracellular domain of
CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2. CAR-D1
is shown by sedimentation velocity to be monomeric at pH 3.0. The solution
structure and the dynamic properties of monomeric CAR-D1 have been determined by
NMR spectroscopy at pH 3.0. The determinants of the CAR-D1 monomer-dimer
equilibrium, as well as the binding site of CVB and Ad on CAR, are discussed in
light of the monomer structure.
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