PDBsum entry 1rsf

Signaling protein

PDB id

1rsf

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Contents

			Protein chain

					126 a.a. *

* Residue conservation analysis

PDB id:

1rsf

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Signaling protein

Title:

Nmr structure of monomeric car d1 domain

Structure:

Coxsackievirus and adenovirus receptor. Chain: a. Synonym: coxsackievirus b-adenovirus receptor, hcar, cvb3 binding protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxadr, car. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

NMR struc:

30 models

Authors:

S.Jiang,A.Jacobs,T.M.Laue,M.Caffrey

Key ref:

S.Jiang et al. (2004). Solution structure of the coxsackievirus and adenovirus receptor domain 1. Biochemistry, 43, 1847-1853. PubMed id: 14967025 DOI: 10.1021/bi035490x

Date:

09-Dec-03

Release date:

02-Mar-04

PROCHECK

	Headers

	References

Protein chain

P78310 (CXAR_HUMAN) - Coxsackievirus and adenovirus receptor from Homo sapiens

Seq: Struc:					365 a.a. 126 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1021/bi035490x	Biochemistry 43:1847-1853 (2004)
PubMed id: 14967025

Solution structure of the coxsackievirus and adenovirus receptor domain 1.
S.Jiang, A.Jacobs, T.M.Laue, M.Caffrey.

ABSTRACT

The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function of CAR, which is expressed in a wide variety of tissue types, is thought to involve homophilic cell adhesion in the developing brain. The extracellular domain of CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be monomeric at pH 3.0. The solution structure and the dynamic properties of monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The determinants of the CAR-D1 monomer-dimer equilibrium, as well as the binding site of CVB and Ad on CAR, are discussed in light of the monomer structure.

Literature references that cite this PDB file's key reference

PubMed id

Reference

17376928

K.J.Excoffon, N.Gansemer, G.Traver, and J.Zabner (2007).
Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection.

J Virol, 81, 5573-5578.

17322536

S.Jiang, and M.Caffrey (2007).
Solution structure of the coxsackievirus and adenovirus receptor domain 2.

Protein Sci, 16, 539-542.

PDB code:

2npl

16923808

E.Seiradake, H.Lortat-Jacob, O.Billet, E.J.Kremer, and S.Cusack (2006).
Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.

J Biol Chem, 281, 33704-33716.

PDB codes:

2j12 2j1k 2j2j

15864812

D.R.Asher, A.M.Cerny, S.R.Weiler, J.W.Horner, M.L.Keeler, M.A.Neptune, S.N.Jones, R.T.Bronson, R.A.Depinho, and R.W.Finberg (2005).
Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.

Genesis, 42, 77-85.

15778494

K.J.Excoffon, G.L.Traver, and J.Zabner (2005).
The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor.

Am J Respir Cell Mol Biol, 32, 498-503.

15850666

M.Hauwel, E.Furon, and P.Gasque (2005).
Molecular and cellular insights into the coxsackie-adenovirus receptor: role in cellular interactions in the stem cell niche.

Brain Res Brain Res Rev, 48, 265-272.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.