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UniProt functional annotation for Q07343 | ||
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| UniProt code: Q07343. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}. |
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| Catalytic activity: | |
Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}; |
| Activity regulation: | |
Inhibited by rolipram. |
| Pathway: | |
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. |
| Tissue specificity: | |
Expressed in brain, heart, lung and skeletal muscle. |
| Miscellaneous: | |
[Isoform PDE4B5]: Brain-specific isoform. {ECO:0000305}. |
| Similarity: | |
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA35643.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.