UniProt functional annotation for Q9V535



	UniProt functional annotation for Q9V535

UniProt code: Q9V535.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839). {ECO:0000269|PubMed:11691839, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:20946982, ECO:0000269|PubMed:20946983, ECO:0000269|PubMed:24967911}.

Subunit: Heterodimer (via RRM domain) with mago (PubMed:11691839, PubMed:12730685, PubMed:12704080). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N-terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490). {ECO:0000269|PubMed:11691839, ECO:0000269|PubMed:12704080, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:14973490, ECO:0000269|PubMed:24967911}.

Subcellular location: Nucleus {ECO:0000269|PubMed:12730685}. Cytoplasm {ECO:0000269|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.

Developmental stage: Expressed throughout development. Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis. {ECO:0000269|PubMed:11691839}.

Domain: The RNA recognition motif (RRM) is involved in the interaction with mago. The RNA-binding activity of such domains is therefore uncertain. {ECO:0000269|PubMed:12730685}.

Disruption phenotype: Developing photoreceptor cell clusters express reduced levels of rolled/MAPK and fail to differentiate normally. {ECO:0000269|PubMed:20946982, ECO:0000269|PubMed:20946983}.

Miscellaneous: 'Tsunagi' means 'connection' or 'link' in Japanese. {ECO:0000303|PubMed:11691839}.

Similarity: Belongs to the RBM8A family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839). {ECO:0000269\|PubMed:11691839, ECO:0000269\|PubMed:12730685, ECO:0000269\|PubMed:20946982, ECO:0000269\|PubMed:20946983, ECO:0000269\|PubMed:24967911}.


Subunit:		Heterodimer (via RRM domain) with mago (PubMed:11691839, PubMed:12730685, PubMed:12704080). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N-terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490). {ECO:0000269\|PubMed:11691839, ECO:0000269\|PubMed:12704080, ECO:0000269\|PubMed:12730685, ECO:0000269\|PubMed:14968132, ECO:0000269\|PubMed:14973490, ECO:0000269\|PubMed:24967911}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:12730685}. Cytoplasm {ECO:0000269\|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.
Developmental stage:		Expressed throughout development. Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis. {ECO:0000269\|PubMed:11691839}.
Domain:		The RNA recognition motif (RRM) is involved in the interaction with mago. The RNA-binding activity of such domains is therefore uncertain. {ECO:0000269\|PubMed:12730685}.
Disruption phenotype:		Developing photoreceptor cell clusters express reduced levels of rolled/MAPK and fail to differentiate normally. {ECO:0000269\|PubMed:20946982, ECO:0000269\|PubMed:20946983}.
Miscellaneous:		'Tsunagi' means 'connection' or 'link' in Japanese. {ECO:0000303\|PubMed:11691839}.
Similarity:		Belongs to the RBM8A family. {ECO:0000305}.