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UniProt functional annotation for P82804 | ||
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| UniProt code: P82804. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit or components of the translation initiation complex. May not function in cap-dependent translation regulation. {ECO:0000269|PubMed:24967911}. |
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| Subunit: | |
Interacts (via N-terminus) with mago and tsu/RBM8A; the interaction is direct. {ECO:0000269|PubMed:12483225, ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}. Nucleus {ECO:0000269|PubMed:14968132}. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1. {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}. |
| Tissue specificity: | |
Expression detected in the ovary. In the oocyte expressed in the germarium, nurse cell and follicle cell. {ECO:0000269|PubMed:24967911}. |
| Disruption phenotype: | |
Viable and fertile. No visible phenotype. {ECO:0000269|PubMed:24967911}. |
| Similarity: | |
Belongs to the pym family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.