UniProt functional annotation for P49028



	UniProt functional annotation for P49028

UniProt code: P49028.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton (PubMed:8026338, PubMed:9272960). {ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:24967911, ECO:0000269|PubMed:8026338, ECO:0000269|PubMed:9210377, ECO:0000269|PubMed:9272960}.

Subunit: Heterodimer with tsu/RBM8A (PubMed:12704080, PubMed:12730685, PubMed:14968132). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N- terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490). {ECO:0000269|PubMed:12704080, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}.

Subcellular location: Nucleus {ECO:0000269|PubMed:12730685}. Cytoplasm {ECO:0000269|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.

Developmental stage: Expressed both maternally and zygotically (PubMed:8026338). Localizes to the posterior pole of the oocyte during stage 9 of oogenesis (PubMed:14973490). {ECO:0000269|PubMed:14973490, ECO:0000269|PubMed:8026338}.

Miscellaneous: 'Mago nashi' means 'without grandchildren' in Japanese.

Similarity: Belongs to the mago nashi family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton (PubMed:8026338, PubMed:9272960). {ECO:0000269\|PubMed:12730685, ECO:0000269\|PubMed:24967911, ECO:0000269\|PubMed:8026338, ECO:0000269\|PubMed:9210377, ECO:0000269\|PubMed:9272960}.


Subunit:		Heterodimer with tsu/RBM8A (PubMed:12704080, PubMed:12730685, PubMed:14968132). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490). Interacts with Pym (via N- terminus); the interaction is direct (PubMed:24967911, PubMed:14968132). Interacts with eIF4AIII (PubMed:14973490). {ECO:0000269\|PubMed:12704080, ECO:0000269\|PubMed:12730685, ECO:0000269\|PubMed:14968132, ECO:0000269\|PubMed:24967911}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:12730685}. Cytoplasm {ECO:0000269\|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.
Developmental stage:		Expressed both maternally and zygotically (PubMed:8026338). Localizes to the posterior pole of the oocyte during stage 9 of oogenesis (PubMed:14973490). {ECO:0000269\|PubMed:14973490, ECO:0000269\|PubMed:8026338}.
Miscellaneous:		'Mago nashi' means 'without grandchildren' in Japanese.
Similarity:		Belongs to the mago nashi family. {ECO:0000305}.