|
|
||
|
|
|
|
|
UniProt functional annotation for P08661 | ||
|
|
|
|
|
|
||
| UniProt code: P08661. |
|
||
| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
|
||
|
||
| Function: | |
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). {ECO:0000250}. |
|
||
| Subunit: | |
Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Secreted {ECO:0000250}. |
| Domain: | |
The coiled-coil domain mediates trimerization. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.