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PDBsum entry 1r0e
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Glycogen synthase kinase-3 beta in complex with 3-indolyl-4- arylmaleimide inhibitor
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Structure:
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Glycogen synthase kinase-3 beta. Chain: a, b. Synonym: gsk-3 beta. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
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Biol. unit:
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Dimer (from
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Resolution:
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2.25Å
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R-factor:
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0.225
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R-free:
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0.252
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Authors:
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J.Allard,T.Nikolcheva,L.Gong,J.Wang,P.Dunten,Z.Avnur,R.Waters,Q.Sun, B.Skinner
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Key ref:
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J.Allard
et al.
From genetics to therapeutics: the wnt pathway and osteoporosis.
To be published,
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Date:
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20-Sep-03
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Release date:
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12-Oct-04
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PROCHECK
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Headers
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References
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P49841
(GSK3B_HUMAN) -
Glycogen synthase kinase-3 beta from Homo sapiens
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Seq:
Struc:
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420 a.a.
344 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.26
- [tau protein] kinase.
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Reaction:
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1.
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L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H+
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2.
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L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H+
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L-seryl-[tau protein]
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+
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ATP
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=
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O-phospho-L-seryl-[tau protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[tau protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[tau protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
