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UniProt functional annotation for P25746 | ||
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| UniProt code: P25746. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease. {ECO:0000269|PubMed:11278968}. |
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| Subunit: | |
Interacts with CII protein from phage lambda. {ECO:0000269|PubMed:11278968}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11278968}. Cell inner membrane {ECO:0000269|PubMed:11278968}; Peripheral membrane protein {ECO:0000269|PubMed:11278968}; Cytoplasmic side {ECO:0000269|PubMed:11278968}. |
| Disruption phenotype: | |
Cells lacking this gene show an increased lysogenization frequency. {ECO:0000269|PubMed:11278968}. |
| Similarity: | |
Belongs to the HflD family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=M74924; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.