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UniProt functional annotation for P97571 | ||
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| UniProt code: P97571. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-364', 'Gly-377' and 'His-399'. {ECO:0000250|UniProtKB:P07384}. |
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| Catalytic activity: | |
Reaction=Broad endopeptidase specificity.; EC=3.4.22.52; Evidence={ECO:0000250|UniProtKB:P07384}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:P07384}; Note=Binds 4 Ca(2+) ions. {ECO:0000250|UniProtKB:P07384}; |
| Activity regulation: | |
Activated by micromolar concentrations of calcium and inhibited by calpastatin. {ECO:0000250|UniProtKB:P07384}. |
| Subunit: | |
Forms a heterodimer with a small (regulatory) subunit CAPNS1. {ECO:0000269|PubMed:15491615}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250|UniProtKB:P07384}. Cell membrane {ECO:0000250|UniProtKB:P07384}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250|UniProtKB:P07384}. |
| Ptm: | |
Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity). {ECO:0000250|UniProtKB:P07384}. |
| Similarity: | |
Belongs to the peptidase C2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.