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Contents |
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274 a.a.
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100 a.a.
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200 a.a.
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243 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Immune system
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Title:
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Crystal structure of human a6 tcr complexed with hla-a2 bound to altered htlv-1 tax peptide p6a
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Structure:
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Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a. Synonym: mhc class i hla-a. Mhc class i antigen. Lymphocyte antigen. Engineered: yes. Beta-2 microglobulin. Chain: b. Engineered: yes. Tax peptide p6a. Chain: c.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Expression_system_taxid: 562
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Biol. unit:
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Pentamer (from
)
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Resolution:
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2.80Å
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R-factor:
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0.216
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R-free:
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0.273
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Authors:
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Y.H.Ding,B.M.Baker,D.N.Garboczi,W.E.Biddison,D.C.Wiley
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Key ref:
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Y.H.Ding
et al.
(1999).
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.
Immunity,
11,
45-56.
PubMed id:
DOI:
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Date:
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14-Jun-99
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Release date:
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14-Oct-99
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PROCHECK
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Headers
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References
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P04439
(1A03_HUMAN) -
HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
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Seq:
Struc:
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365 a.a.
274 a.a.*
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P61769
(B2MG_HUMAN) -
Beta-2-microglobulin from Homo sapiens
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Seq:
Struc:
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119 a.a.
100 a.a.*
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DOI no:
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Immunity
11:45-56
(1999)
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PubMed id:
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| |
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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.
|
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Y.H.Ding,
B.M.Baker,
D.N.Garboczi,
W.E.Biddison,
D.C.Wiley.
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ABSTRACT
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The interactions of three singly substituted peptide variants of the HTLV-1 Tax
peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T
cell assays, kinetic and thermodynamic measurements, and X-ray crystallography.
The three peptide/MHC ligands include weak agonists and antagonists with
different affinities for TCR. The three-dimensional structures of the three
A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the
wild-type agonist complex, with minor adjustments at the interface to
accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of
correlation between structural changes and the type of T cell signals induced
provides direct evidence that different signals are not generated by different
ligand-induced conformational changes in the alphabeta TCR.
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Selected figure(s)
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The above figures are
reprinted
by permission from Cell Press:
Immunity
(1999,
11,
45-56)
copyright 1999.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
|
| |
PLoS One,
6,
e17194.
|
|
|
|
|
|
|
L.K.Selin,
M.F.Wlodarczyk,
A.R.Kraft,
S.Nie,
L.L.Kenney,
R.Puzone,
and
F.Celada
(2011).
Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.
|
| |
Autoimmunity,
44,
328-347.
|
|
|
|
|
|
|
S.J.Davis,
and
P.A.van der Merwe
(2011).
Lck and the nature of the T cell receptor trigger.
|
| |
Trends Immunol,
32,
1-5.
|
|
|
|
|
|
|
A.Schiefner,
M.Fujio,
D.Wu,
C.H.Wong,
and
I.A.Wilson
(2009).
Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands.
|
| |
J Mol Biol,
394,
71-82.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
| |
J Biol Chem,
284,
27281-27289.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.N.Haidar,
B.Pierce,
Y.Yu,
W.Tong,
M.Li,
and
Z.Weng
(2009).
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.
|
| |
Proteins,
74,
948-960.
|
|
|
|
|
|
|
K.H.Piepenbrink,
O.Y.Borbulevych,
R.F.Sommese,
J.Clemens,
K.M.Armstrong,
C.Desmond,
P.Do,
and
B.M.Baker
(2009).
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.
|
| |
Biochem J,
423,
353-361.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Rubtsova,
J.P.Scott-Browne,
F.Crawford,
S.Dai,
P.Marrack,
and
J.W.Kappler
(2009).
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
|
| |
Proc Natl Acad Sci U S A,
106,
7951-7956.
|
|
|
|
|
|
|
O.Y.Borbulevych,
K.H.Piepenbrink,
B.E.Gloor,
D.R.Scott,
R.F.Sommese,
D.K.Cole,
A.K.Sewell,
and
B.M.Baker
(2009).
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
|
| |
Immunity,
31,
885-896.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Beddoe,
Z.Chen,
C.S.Clements,
L.K.Ely,
S.R.Bushell,
J.P.Vivian,
L.Kjer-Nielsen,
S.S.Pang,
M.A.Dunstone,
Y.C.Liu,
W.A.Macdonald,
M.A.Perugini,
M.C.Wilce,
S.R.Burrows,
A.W.Purcell,
T.Tiganis,
S.P.Bottomley,
J.McCluskey,
and
J.Rossjohn
(2009).
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
|
| |
Immunity,
30,
777-788.
|
|
|
|
|
|
|
X.Shang,
L.Wang,
W.Niu,
G.Meng,
X.Fu,
B.Ni,
Z.Lin,
Z.Yang,
X.Chen,
and
Y.Wu
(2009).
Rational optimization of tumor epitopes using in silico analysis-assisted substitution of TCR contact residues.
|
| |
Eur J Immunol,
39,
2248-2258.
|
|
|
|
|
|
|
A.Beltrami,
M.Rossmann,
M.T.Fiorillo,
F.Paladini,
R.Sorrentino,
W.Saenger,
P.Kumar,
A.Ziegler,
and
B.Uchanska-Ziegler
(2008).
Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes.
|
| |
J Biol Chem,
283,
27189-27199.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity,
28,
304-314.
|
|
|
|
|
|
|
E.J.Collins,
and
D.S.Riddle
(2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
|
| |
Immunol Res,
41,
267-294.
|
|
|
|
|
|
|
K.M.Armstrong,
K.H.Piepenbrink,
and
B.M.Baker
(2008).
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
|
| |
Biochem J,
415,
183-196.
|
|
|
|
|
|
|
L.G.Petrich de Marquesini,
A.K.Moustakas,
I.J.Thomas,
L.Wen,
G.K.Papadopoulos,
and
F.S.Wong
(2008).
Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands.
|
| |
Eur J Immunol,
38,
240-249.
|
|
|
|
|
|
|
M.A.Cuendet,
and
O.Michielin
(2008).
Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex.
|
| |
Biophys J,
95,
3575-3590.
|
|
|
|
|
|
|
O.Feinerman,
R.N.Germain,
and
G.Altan-Bonnet
(2008).
Quantitative challenges in understanding ligand discrimination by alphabeta T cells.
|
| |
Mol Immunol,
45,
619-631.
|
|
|
|
|
|
|
R.M.Risueño,
W.W.Schamel,
and
B.Alarcón
(2008).
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.
|
| |
PLoS ONE,
3,
e1747.
|
|
|
|
|
|
|
Y.N.Naumov,
E.N.Naumova,
M.B.Yassai,
K.Kota,
R.M.Welsh,
and
L.K.Selin
(2008).
Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus.
|
| |
J Immunol,
181,
7407-7419.
|
|
|
|
|
|
|
Z.Ma,
K.A.Sharp,
P.A.Janmey,
and
T.H.Finkel
(2008).
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
|
| |
PLoS Biol,
6,
e43.
|
|
|
|
|
|
|
C.Mazza,
N.Auphan-Anezin,
C.Gregoire,
A.Guimezanes,
C.Kellenberger,
A.Roussel,
A.Kearney,
P.A.van der Merwe,
A.M.Schmitt-Verhulst,
and
B.Malissen
(2007).
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
|
| |
EMBO J,
26,
1972-1983.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.McCarthy,
D.Shepherd,
S.Fleire,
V.S.Stronge,
M.Koch,
P.A.Illarionov,
G.Bossi,
M.Salio,
G.Denkberg,
F.Reddington,
A.Tarlton,
B.G.Reddy,
R.R.Schmidt,
Y.Reiter,
G.M.Griffiths,
P.A.van der Merwe,
G.S.Besra,
E.Y.Jones,
F.D.Batista,
and
V.Cerundolo
(2007).
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
|
| |
J Exp Med,
204,
1131-1144.
|
|
|
|
|
|
|
F.E.Tynan,
H.H.Reid,
L.Kjer-Nielsen,
J.J.Miles,
M.C.Wilce,
L.Kostenko,
N.A.Borg,
N.A.Williamson,
T.Beddoe,
A.W.Purcell,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2007).
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
|
| |
Nat Immunol,
8,
268-276.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Choudhuri,
and
P.A.van der Merwe
(2007).
Molecular mechanisms involved in T cell receptor triggering.
|
| |
Semin Immunol,
19,
255-261.
|
|
|
|
|
|
|
K.M.Armstrong,
and
B.M.Baker
(2007).
A comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction.
|
| |
Biophys J,
93,
597-609.
|
|
|
|
|
|
|
O.Y.Borbulevych,
F.K.Insaidoo,
T.K.Baxter,
D.J.Powell,
L.A.Johnson,
N.P.Restifo,
and
B.M.Baker
(2007).
Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.
|
| |
J Mol Biol,
372,
1123-1136.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
and
E.J.Collins
(2007).
Single MHC mutation eliminates enthalpy associated with T cell receptor binding.
|
| |
J Mol Biol,
373,
315-327.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Minguet,
M.Swamy,
B.Alarcón,
I.F.Luescher,
and
W.W.Schamel
(2007).
Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
|
| |
Immunity,
26,
43-54.
|
|
|
|
|
|
|
A.Franco,
and
S.Albani
(2006).
Translating the concept of suppressor/regulatory T cells to clinical applications.
|
| |
Int Rev Immunol,
25,
27-47.
|
|
|
|
|
|
|
C.Thilo,
P.Berglund,
S.E.Applequist,
J.W.Yewdell,
H.G.Ljunggren,
and
A.Achour
(2006).
Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.
|
| |
J Biol Chem,
281,
8950-8957.
|
|
|
|
|
|
|
E.Martinez-Hackert,
N.Anikeeva,
S.A.Kalams,
B.D.Walker,
W.A.Hendrickson,
and
Y.Sykulev
(2006).
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
|
| |
J Biol Chem,
281,
20205-20212.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.K.Selin,
M.A.Brehm,
Y.N.Naumov,
M.Cornberg,
S.K.Kim,
S.C.Clute,
and
R.M.Welsh
(2006).
Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.
|
| |
Immunol Rev,
211,
164-181.
|
|
|
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|
M.G.Rudolph,
R.L.Stanfield,
and
I.A.Wilson
(2006).
How TCRs bind MHCs, peptides, and coreceptors.
|
| |
Annu Rev Immunol,
24,
419-466.
|
|
|
|
|
|
|
M.Uhlin,
M.Masucci,
and
V.Levitsky
(2006).
Is the activity of partially agonistic MHC:peptide ligands dependent on the quality of immunological help?
|
| |
Scand J Immunol,
64,
581-587.
|
|
|
|
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|
|
P.J.Norris,
J.D.Stone,
N.Anikeeva,
J.W.Heitman,
I.C.Wilson,
D.F.Hirschkorn,
M.J.Clark,
H.F.Moffett,
T.O.Cameron,
Y.Sykulev,
L.J.Stern,
and
B.D.Walker
(2006).
Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
|
| |
Mol Immunol,
43,
1349-1357.
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|
|
R.L.Stanfield,
M.K.Gorny,
S.Zolla-Pazner,
and
I.A.Wilson
(2006).
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.
|
| |
J Virol,
80,
6093-6105.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.J.Turner,
P.C.Doherty,
J.McCluskey,
and
J.Rossjohn
(2006).
Structural determinants of T-cell receptor bias in immunity.
|
| |
Nat Rev Immunol,
6,
883-894.
|
|
|
|
|
|
|
W.W.Schamel,
R.M.Risueño,
S.Minguet,
A.R.Ortíz,
and
B.Alarcón
(2006).
A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex.
|
| |
Trends Immunol,
27,
176-182.
|
|
|
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|
|
|
B.Laugel,
J.M.Boulter,
N.Lissin,
A.Vuidepot,
Y.Li,
E.Gostick,
L.E.Crotty,
D.C.Douek,
J.Hemelaar,
D.A.Price,
B.K.Jakobsen,
and
A.K.Sewell
(2005).
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
|
| |
J Biol Chem,
280,
1882-1892.
|
|
|
|
|
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|
H.Li,
S.Van Vranken,
Y.Zhao,
Z.Li,
Y.Guo,
L.Eisele,
and
Y.Li
(2005).
Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.
|
| |
Protein Sci,
14,
3025-3038.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.C.Huang,
R.J.Ober,
and
E.S.Ward
(2005).
The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis.
|
| |
Eur J Immunol,
35,
299-304.
|
|
|
|
|
|
|
J.L.Chen,
G.Stewart-Jones,
G.Bossi,
N.M.Lissin,
L.Wooldridge,
E.M.Choi,
G.Held,
P.R.Dunbar,
R.M.Esnouf,
M.Sami,
J.M.Boulter,
P.Rizkallah,
C.Renner,
A.Sewell,
P.A.van der Merwe,
B.K.Jakobsen,
G.Griffiths,
E.Y.Jones,
and
V.Cerundolo
(2005).
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
|
| |
J Exp Med,
201,
1243-1255.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.Hülsmeyer,
P.Chames,
R.C.Hillig,
R.L.Stanfield,
G.Held,
P.G.Coulie,
C.Alings,
G.Wille,
W.Saenger,
B.Uchanska-Ziegler,
H.R.Hoogenboom,
and
A.Ziegler
(2005).
A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3.
|
| |
J Biol Chem,
280,
2972-2980.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Krogsgaard,
and
M.M.Davis
(2005).
How T cells 'see' antigen.
|
| |
Nat Immunol,
6,
239-245.
|
|
|
|
|
|
|
N.A.Borg,
L.K.Ely,
T.Beddoe,
W.A.Macdonald,
H.H.Reid,
C.S.Clements,
A.W.Purcell,
L.Kjer-Nielsen,
J.J.Miles,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2005).
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.
|
| |
Nat Immunol,
6,
171-180.
|
|
|
|
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J Immunol,
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|
PDB codes:
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|
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|
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|
|
S.Cho,
C.P.Swaminathan,
J.Yang,
M.C.Kerzic,
R.Guan,
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Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
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Structure,
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S.E.Levin,
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J Exp Med,
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Philos Transact A Math Phys Eng Sci,
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T.Sandalova,
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A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.
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| |
J Biol Chem,
280,
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PDB code:
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|
|
|
W.W.Schamel,
I.Arechaga,
R.M.Risueño,
H.M.van Santen,
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Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.
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J Exp Med,
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B.Goldstein,
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Mathematical and computational models of immune-receptor signalling.
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Nat Rev Immunol,
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D.M.Gakamsky,
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T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit.
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Proc Natl Acad Sci U S A,
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J.K.Lee,
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T.Dong,
K.Harlos,
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P.A.van der Merwe,
E.Y.Jones,
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A.J.McMichael
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T cell cross-reactivity and conformational changes during TCR engagement.
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| |
J Exp Med,
200,
1455-1466.
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|
PDB codes:
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|
|
|
|
|
|
|
T.K.Baxter,
S.J.Gagnon,
R.L.Davis-Harrison,
J.C.Beck,
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R.V.Turner,
W.E.Biddison,
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Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition.
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J Biol Chem,
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J Biol Chem,
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B.Alarcón,
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Immunol Rev,
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J Exp Med,
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Trends Immunol,
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A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
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| |
Immunity,
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PDB code:
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|
J.Yang,
C.P.Swaminathan,
Y.Huang,
R.Guan,
S.Cho,
M.C.Kieke,
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Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.
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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
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Immunity,
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PDB code:
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|
M.Krogsgaard,
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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
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| |
Mol Cell,
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PDB codes:
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|
M.M.Davis,
M.Krogsgaard,
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A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
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Immunity,
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PDB codes:
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|
B.Holm,
J.Bäcklund,
M.A.Recio,
R.Holmdahl,
and
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Glycopeptide specificity of helper T cells obtained in mouse models for rheumatoid arthritis.
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Chembiochem,
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C.Grant,
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Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation.
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J Cell Physiol,
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D.Gil,
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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
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| |
Cell,
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J.G.Luz,
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| |
J Exp Med,
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PDB codes:
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|
J.Hennecke,
and
D.C.Wiley
(2002).
Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
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| |
J Exp Med,
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PDB code:
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|
K.Natarajan,
N.Dimasi,
J.Wang,
R.A.Mariuzza,
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Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.
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Annu Rev Immunol,
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L.Kjer-Nielsen,
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A.G.Brooks,
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The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.
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| |
Structure,
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PDB code:
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|
M.G.Rudolph,
and
I.A.Wilson
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The specificity of TCR/pMHC interaction.
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Curr Opin Immunol,
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M.G.Rudolph,
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Annu Rev Biophys Biomol Struct,
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T.Yokosuka,
K.Takase,
M.Suzuki,
Y.Nakagawa,
S.Taki,
H.Takahashi,
T.Fujisawa,
H.Arase,
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Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system.
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J Exp Med,
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B.M.Baker,
R.V.Turner,
S.J.Gagnon,
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W.E.Biddison
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Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors.
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J Exp Med,
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J.Buslepp,
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D.Loftus,
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E.Appella,
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T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface.
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| |
J Biol Chem,
276,
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PDB codes:
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|
J.H.Wang,
R.Meijers,
Y.Xiong,
J.H.Liu,
T.Sakihama,
R.Zhang,
A.Joachimiak,
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
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| |
Proc Natl Acad Sci U S A,
98,
10799-10804.
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PDB code:
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|
J.Hennecke,
and
D.C.Wiley
(2001).
T cell receptor-MHC interactions up close.
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Cell,
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J.Neilson,
K.Stankunas,
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Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.
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Curr Opin Immunol,
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J.R.Cochran,
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Receptor clustering and transmembrane signaling in T cells.
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Trends Biochem Sci,
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K.C.Garcia,
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Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis.
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Proc Natl Acad Sci U S A,
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J Autoimmun,
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M.G.Rudolph,
J.A.Speir,
A.Brunmark,
N.Mattsson,
M.R.Jackson,
P.A.Peterson,
L.Teyton,
and
I.A.Wilson
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The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
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| |
Immunity,
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|
PDB codes:
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|
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|
M.Regner
(2001).
Cross-reactivity in T-cell antigen recognition.
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| |
Immunol Cell Biol,
79,
91.
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Z.J.Sun,
K.S.Kim,
G.Wagner,
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E.L.Reinherz
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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
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| |
Cell,
105,
913-923.
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PDB code:
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|
|
|
|
|
|
|
B.M.Baker,
S.J.Gagnon,
W.E.Biddison,
and
D.C.Wiley
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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.
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| |
Immunity,
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C.R.Bangham
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The immune response to HTLV-I.
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Curr Opin Immunol,
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J.Hennecke,
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Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.
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| |
EMBO J,
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PDB code:
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J.M.Blander,
D.B.Sant'Angelo,
K.Bottomly,
and
C.A.Janeway
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Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
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J Exp Med,
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A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions.
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Chem Biol,
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J.R.Cochran,
T.O.Cameron,
and
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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers.
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| |
Immunity,
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J.Yagüe,
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A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand.
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M.Degano,
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L.Teyton,
and
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(2000).
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
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| |
Immunity,
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|
|
PDB code:
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|
P.Anton van der Merwe,
S.J.Davis,
A.S.Shaw,
and
M.L.Dustin
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Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition.
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Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors.
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E.L.Reinherz,
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Y.Xiong,
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The crystal structure of a T cell receptor in complex with peptide and MHC class II.
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| |
Science,
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PDB code:
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|
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|
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|
K.Maenaka,
and
E.Y.Jones
(1999).
MHC superfamily structure and the immune system.
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Curr Opin Struct Biol,
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
| |
Links
