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PDBsum entry 1q70
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Immune system
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PDB id
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1q70
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DOI no:
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Neurobiol Dis
9:160-172
(2002)
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PubMed id:
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Marmoset fine B cell and T cell epitope specificities mapped onto a homology model of the extracellular domain of human myelin oligodendrocyte glycoprotein.
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M.F.Mesleh,
N.Belmar,
C.W.Lu,
V.V.Krishnan,
R.S.Maxwell,
C.P.Genain,
M.Cosman.
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ABSTRACT
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Aberrant association of autoantibodies with myelin oligodendrocyte glycoprotein
(MOG), an integral membrane protein of the central nervous system (CNS) myelin,
has been implicated in the pathogenesis of multiple sclerosis (MS).
Sensitization of nonhuman primates (Callithrix jacchus marmosets) against the
nonglycosylated, recombinant N-terminal domain of rat MOG (residues 1-125)
reproduces an MS-like disease in which MOG-specific autoantibodies directly
mediate demyelination. To assess the interrelationship between MOG structure and
the induction of autoimmune CNS diseases and to enable structure-based rational
design of therapeutics, a homology model of human MOG(2-120) was constructed
based on consensus residues found in immunoglobulin superfamily variable-type
proteins having known structures. Possible sites for posttranslational
modifications and dimerization have also been identified and analyzed. The B
cell and T cell epitopes have been identified in rat MOG-immunized marmosets,
and these sequences are observed to map primarily onto accessible regions in the
model, which may explain their ability to generate potent antibody responses.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.A.Jagessar,
Y.S.Kap,
N.Heijmans,
N.van Driel,
L.van Straalen,
J.J.Bajramovic,
H.P.Brok,
E.L.Blezer,
J.Bauer,
J.D.Laman,
and
B.A.'t Hart
(2010).
Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete freund adjuvant.
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J Neuropathol Exp Neurol,
69,
372-385.
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B.A.'t Hart,
and
L.Massacesi
(2009).
Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus).
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J Neuropathol Exp Neurol,
68,
341-355.
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K.Hawker
(2008).
B-cell-targeted treatment for multiple sclerosis: mechanism of action and clinical data.
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Curr Opin Neurol,
21,
S19-S25.
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C.Delarasse,
B.Della Gaspera,
C.W.Lu,
F.Lachapelle,
A.Gelot,
D.Rodriguez,
A.Dautigny,
C.Genain,
and
D.Pham-Dinh
(2006).
Complex alternative splicing of the myelin oligodendrocyte glycoprotein gene is unique to human and non-human primates.
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J Neurochem,
98,
1707-1717.
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P.H.Lalive,
T.Menge,
C.Delarasse,
B.Della Gaspera,
D.Pham-Dinh,
P.Villoslada,
H.C.von Büdingen,
and
C.P.Genain
(2006).
Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis.
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Proc Natl Acad Sci U S A,
103,
2280-2285.
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H.C.von Büdingen,
S.L.Hauser,
A.Fuhrmann,
C.B.Nabavi,
J.I.Lee,
and
C.P.Genain
(2002).
Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination.
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Proc Natl Acad Sci U S A,
99,
8207-8212.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
